Attractin precursor - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Attractin
Alternative name(s):
    Mahogany homolog
    DPPT-L

Gene names

Name:	ATRN
Synonyms:	KIAA0548, MGCA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti By similarity. Has a critical role in normal myelination in the central nervous system By similarity.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted.
Tissue specificity	Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2/secreted is the major isoform in peripheral blood leukocytes. Ref.1
Induction	Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.
Sequence similarities	Contains 1 C-type lectin domain. Contains 1 CUB domain. Contains 1 EGF-like domain. Contains 6 Kelch repeats. Contains 2 laminin EGF-like domains.

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Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Kelch repeat Laminin EGF-like domain Repeat Signal Transmembrane
Ligand	Lectin
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Ref.5 Traceable author statement. Source: ProtInc integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Traceable author statement. Source: ProtInc sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75882-1) Also known as: Membrane; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75882-2) Also known as: Secreted; The sequence of this isoform differs from the canonical sequence as follows: 1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Isoform 3 (identifier: O75882-3) The sequence of this isoform differs from the canonical sequence as follows: 31-104: Missing. 1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 15

15

Potential

Chain

16 – 1429

1414

Attractin

PRO_0000007483

Regions

Topological domain

16 – 1279

1264

Extracellular Potential

Transmembrane

1280 – 1300

21

Potential

Topological domain

1301 – 1429

129

Cytoplasmic Potential

Domain

101 – 129

29

EGF-like

Domain

132 – 248

117

CUB

Repeat

352 – 402

51

Kelch 1

Repeat

404 – 451

48

Kelch 2

Repeat

461 – 508

48

Kelch 3

Repeat

513 – 564

52

Kelch 4

Repeat

566 – 624

59

Kelch 5

Repeat

625 – 671

47

Kelch 6

Domain

795 – 919

125

C-type lectin

Domain

1063 – 1108

46

Laminin EGF-like 1

Domain

1109 – 1157

49

Laminin EGF-like 2

Compositional bias

43 – 77

35

Leu-rich

Compositional bias

81 – 89

9

Poly-Ala

Amino acid modifications

Glycosylation

213

1

N-linked (GlcNAc...) Potential

Glycosylation

237

1

N-linked (GlcNAc...) Potential

Glycosylation

242

1

N-linked (GlcNAc...) Potential

Glycosylation

253

1

N-linked (GlcNAc...) Potential

Glycosylation

264

1

N-linked (GlcNAc...) Ref.7 Ref.8

Glycosylation

300

1

N-linked (GlcNAc...) Ref.8

Glycosylation

325

1

N-linked (GlcNAc...) Potential

Glycosylation

362

1

N-linked (GlcNAc...) Potential

Glycosylation

383

1

N-linked (GlcNAc...) Ref.7 Ref.8

Glycosylation

416

1

N-linked (GlcNAc...) Ref.8

Glycosylation

428

1

N-linked (GlcNAc...) Ref.8

Glycosylation

575

1

N-linked (GlcNAc...) Ref.8

Glycosylation

623

1

N-linked (GlcNAc...) Ref.8

Glycosylation

731

1

N-linked (GlcNAc...) Ref.7

Glycosylation

863

1

N-linked (GlcNAc...) Potential

Glycosylation

914

1

N-linked (GlcNAc...) Potential

Glycosylation

923

1

N-linked (GlcNAc...) Potential

Glycosylation

986

1

N-linked (GlcNAc...) Potential

Glycosylation

1043

1

N-linked (GlcNAc...) Ref.8

Glycosylation

1054

1

N-linked (GlcNAc...) Potential

Glycosylation

1073

1

N-linked (GlcNAc...) Potential

Glycosylation

1082

1

N-linked (GlcNAc...) Potential

Glycosylation

1198

1

N-linked (GlcNAc...) Ref.8

Glycosylation

1206

1

N-linked (GlcNAc...) Potential

Glycosylation

1250

1

N-linked (GlcNAc...) Ref.8

Glycosylation

1259

1

N-linked (GlcNAc...) Ref.8

Disulfide bond

101 ↔ 111

By similarity

Disulfide bond

105 ↔ 118

By similarity

Disulfide bond

120 ↔ 129

By similarity

Disulfide bond

250 ↔ 260

By similarity

Disulfide bond

254 ↔ 271

By similarity

Disulfide bond

273 ↔ 282

By similarity

Disulfide bond

816 ↔ 918

By similarity

Disulfide bond

1063 ↔ 1071

By similarity

Disulfide bond

1065 ↔ 1077

By similarity

Disulfide bond

1080 ↔ 1089

By similarity

Disulfide bond

1092 ↔ 1106

By similarity

Disulfide bond

1127 ↔ 1137

By similarity

Disulfide bond

1140 ↔ 1155

By similarity

Natural variations

Alternative sequence

31 – 104

74

Missing in isoform 3.

VSP_001372

Alternative sequence

1268 – 1429

162

IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3.

VSP_001375

Natural variant

303

1

D → A: dbSNP rs6107308.

VAR_048967

Natural variant

426

1

I → T: dbSNP rs17782078.

VAR_048968

Natural variant

1152

1

R → K: dbSNP rs3886999.

VAR_048969

Natural variant

1226

1

V → I: dbSNP rs12329487.

VAR_048970

Experimental info

Sequence conflict

69

1

S → P in AAD03057. Ref.2

Sequence conflict

267

1

D → E in AAD03057. Ref.2

Sequence conflict

413

1

S → P in AAD03057. Ref.2

Sequence conflict

1172

1

E → K in AAF72881 and AAF72882. Ref.1

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Membrane) [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 9F206A319B7E3DD8 Show »	FASTA	1,429	158,537
10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 70 80 90 100 110 120 LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 130 140 150 160 170 180 PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 190 200 210 220 230 240 CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 250 260 270 280 290 300 FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 310 320 330 340 350 360 SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 370 380 390 400 410 420 FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 430 440 450 460 470 480 LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 490 500 510 520 530 540 DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 550 560 570 580 590 600 TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 610 620 630 640 650 660 SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 670 680 690 700 710 720 GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 730 740 750 760 770 780 HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 790 800 810 820 830 840 IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 850 860 870 880 890 900 IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 910 920 930 940 950 960 TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 970 980 990 1000 1010 1020 SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 1030 1040 1050 1060 1070 1080 YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1090 1100 1110 1120 1130 1140 ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 1150 1160 1170 1180 1190 1200 EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1210 1220 1230 1240 1250 1260 KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 1270 1280 1290 1300 1310 1320 TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM 1330 1340 1350 1360 1370 1380 QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP CFGNKAAVLS VFVRLPRGLG 1390 1400 1410 1420 GIPPPGQSGL AVASALVDIS QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI « Hide
Isoform 2 (Secreted). Checksum: B2DD527761F6FCEE Show »		1,272	141,429
10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP RLLSPPLRPR 70 80 90 100 110 120 LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 130 140 150 160 170 180 PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG NYKYKTKCTW LIEGQPNRIM RLRFNHFATE 190 200 210 220 230 240 CSWDHLYVYD GDSIYAPLVA AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 250 260 270 280 290 300 FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 310 320 330 340 350 360 SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 370 380 390 400 410 420 FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY KDKIYMYGGK IDSTGNVTNE 430 440 450 460 470 480 LRVFHIHNES WVLLTPKAKE QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 490 500 510 520 530 540 DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD 550 560 570 580 590 600 TQMWTILKDS RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 610 620 630 640 650 660 SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA HRSEAACLAA 670 680 690 700 710 720 GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC 730 740 750 760 770 780 HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT SCRSCALDQN CQWEPRNQEC 790 800 810 820 830 840 IALPENICGI GWHLVGNSCL KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 850 860 870 880 890 900 IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 910 920 930 940 950 960 TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM WCSNMKQCVD 970 980 990 1000 1010 1020 SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP GCGWCTDPSN TGKGKCIEGS 1030 1040 1050 1060 1070 1080 YKGPVKMPSQ APTGNFYPQP LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1090 1100 1110 1120 1130 1140 ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC 1150 1160 1170 1180 1190 1200 EVENRYQGNP LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1210 1220 1230 1240 1250 1260 KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN ITFFVYVSNF 1270 TWPIKIQVQT EQ « Hide
Isoform 3. Checksum: 29173E6048FE995E Show »		1,198	133,702
10 20 30 40 50 60 MVAAAAATEA RLRRRTAATA ALAGRSGGPH CVNGGRCNPG TGQCVCPAGW VGEQCQHCGG 70 80 90 100 110 120 RFRLTGSSGF VTDGPGNYKY KTKCTWLIEG QPNRIMRLRF NHFATECSWD HLYVYDGDSI 130 140 150 160 170 180 YAPLVAAFSG LIVPERDGNE TVPEVVATSG YALLHFFSDA AYNLTGFNIT YSFDMCPNNC 190 200 210 220 230 240 SGRGECKISN SSDTVECECS ENWKGEACDI PHCTDNCGFP HRGICNSSDV RGCSCFSDWQ 250 260 270 280 290 300 GPGCSVPVPA NQSFWTREEY SNLKLPRASH KAVVNGNIMW VVGGYMFNHS DYNMVLAYDL 310 320 330 340 350 360 ASREWLPLNR SVNNVVVRYG HSLALYKDKI YMYGGKIDST GNVTNELRVF HIHNESWVLL 370 380 390 400 410 420 TPKAKEQYAV VGHSAHIVTL KNGRVVMLVI FGHCPLYGYI SNVQEYDLDK NTWSILHTQG 430 440 450 460 470 480 ALVQGGYGHS SVYDHRTRAL YVHGGYKAFS ANKYRLADDL YRYDVDTQMW TILKDSRFFR 490 500 510 520 530 540 YLHTAVIVSG TMLVFGGNTH NDTSMSHGAK CFSSDFMAYD IACDRWSVLP RPDLHHDVNR 550 560 570 580 590 600 FGHSAVLHNS TMYVFGGFNS LLLSDILVFT SEQCDAHRSE AACLAAGPGI RCVWNTGSSQ 610 620 630 640 650 660 CISWALATDE QEEKLKSECF SKRTLDHDRC DQHTDCYSCT ANTNDCHWCN DHCVPRNHSC 670 680 690 700 710 720 SEGQISIFRY ENCPKDNPMY YCNKKTSCRS CALDQNCQWE PRNQECIALP ENICGIGWHL 730 740 750 760 770 780 VGNSCLKITT AKENYDNAKL FCRNHNALLA SLTTQKKVEF VLKQLRIMQS SQSMSKLTLT 790 800 810 820 830 840 PWVGLRKINV SYWCWEDMSP FTNSLLQWMP SEPSDAGFCG ILSEPSTRGL KAATCINPLN 850 860 870 880 890 900 GSVCERPANH SAKQCRTPCA LRTACGDCTS GSSECMWCSN MKQCVDSNAY VASFPFGQCM 910 920 930 940 950 960 EWYTMSTCPP ENCSGYCTCS HCLEQPGCGW CTDPSNTGKG KCIEGSYKGP VKMPSQAPTG 970 980 990 1000 1010 1020 NFYPQPLLNS SMCLEDSRYN WSFIHCPACQ CNGHSKCINQ SICEKCENLT TGKHCETCIS 1030 1040 1050 1060 1070 1080 GFYGDPTNGG KCQPCKCNGH ASLCNTNTGK CFCTTKGVKG DECQLCEVEN RYQGNPLRGT 1090 1100 1110 1120 1130 1140 CYYTLLIDYQ FTFSLSQEDD RYYTAINFVA TPDEQNRDLD MFINASKNFN LNITWAASFS 1150 1160 1170 1180 1190 AGTQAGEEMP VVSKTNIKEY KDSFSNEKFD FRNHPNITFF VYVSNFTWPI KIQVQTEQ « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted and membrane attractin result from alternative splicing of the human ATRN gene." Tang W., Gunn T.M., McLaughlin D.F., Barsh G.S., Schlossman S.F., Duke-Cohan J.S. Proc. Natl. Acad. Sci. U.S.A. 97:6025-6030(2000) [PubMed: 10811918] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]	"Cloning of cDNA for attractin-2, identical with that of attractin except for a GC-rich 222 bp 5' insertion." Duke-Cohan J.S., Gu J., Freeman G.J., Schlossman S.F. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M.,

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References