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Reviewed, UniProtKB/Swiss-Prot O75970 (MPDZ_HUMAN)

Last modified December 16, 2008. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Multiple PDZ domain protein
Alternative name(s):
    Multi-PDZ domain protein 1
Gene names
Name: MPDZ
Synonyms: MUPP1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length2042 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Interacts with HTR2C and provokes its clustering at the cell surface By similarity. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.

Subunit structure

Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 By similarity. Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell projection › dendrite. Cell junction › synapse. Cell junction › tight junction. Cell junction › synapse. Cell junction › synapse › synaptosome. Note= Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells By similarity. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.

Tissue specificity

Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Ref.6

Domain

The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR By similarity. The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1.

Sequence similarities

Contains 1 L27 domain.

Contains 13 PDZ (DHR) domains.

Sequence caution

The sequence CAI40490.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40491.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40494.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40495.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI41236.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI41237.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI41240.1 differs from that shown. Reason: Erroneous gene model prediction.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

ABCA1O954771EBI-821405,EBI-784112

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75970-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75970-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1809-1809: G → GPFHSERRPSQSSQVSEGSLSSFTFPLSG
Isoform 3 (identifier: O75970-3)

The sequence of this isoform differs from the canonical sequence as follows:
     647-696: Missing.
     1211-1280: Missing.
     1809-1809: G → GPFHSERRPSQSSQVSEGSLSSFTFPLSG

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20422042Multiple PDZ domain protein
PRO_0000094594

Regions

Domain1 – 6363L27
Domain137 – 22488PDZ 1
Domain257 – 33781PDZ 2
Domain377 – 46387PDZ 3
Domain553 – 63482PDZ 4
Domain700 – 78687PDZ 5
Domain1008 – 108982PDZ 6
Domain1151 – 124393PDZ 7
Domain1350 – 143384PDZ 8
Domain1483 – 156482PDZ 9
Domain1629 – 171284PDZ 10
Domain1725 – 180783PDZ 11
Domain1834 – 192087PDZ 12
Domain1959 – 204284PDZ 13

Amino acid modifications

Modified residue2301Phosphoserine Ref.14 Ref.15
Modified residue3531Phosphoserine Ref.15
Modified residue3581Phosphothreonine Ref.15
Modified residue4831Phosphoserine Ref.13

Natural variations

Alternative sequence647 – 69650Missing in isoform 3.
VSP_014196
Alternative sequence1211 – 128070Missing in isoform 3.
VSP_014197
Alternative sequence18091G → GPFHSERRPSQSSQVSEGSL SSFTFPLSG in isoform 2 and isoform 3.
VSP_014198

Experimental info

Mutagenesis147 – 1504GLGF → PSES: Loss of interaction with CAMK2A Ref.12
Sequence conflict19221V → M in CAI56786. Ref.4

Secondary structure

1 ......................................................................................................... 2042
Helix Strand Turn

Details...