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Reviewed, UniProtKB/Swiss-Prot O76011 (KRT34_HUMAN)

Last modified December 16, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Keratin, type I cuticular Ha4
Alternative name(s):
    Hair keratin, type I Ha4
    Keratin-34
      Short name=K34
Gene names
Name: KRT34
Synonyms: HHA4, HKA4, KRTHA4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

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Ontologies

Keywords

   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil

Gene Ontology (GO)

   Biological processepidermis development Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

structural molecule activity Ref.1

Non-traceable author statement. Source: ProtInc

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

DLG3Q927961EBI-1047093,EBI-80440
PLEKHB2Q96CS71EBI-1047093,EBI-373552

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Keratin, type I cuticular Ha4
PRO_0000063691

Regions

Region1 – 5656Head
Region57 – 363307Rod
Region57 – 9135Coil 1A
Region92 – 10211Linker 1
Region103 – 203101Coil 1B
Region204 – 21916Linker 12
Region220 – 363144Coil 2
Region364 – 39431Tail

Sites

Site3051Stutter

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Sequences

Sequence LengthMass (Da)Tools
O76011-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: A651BF32918A98BF

FASTA39444,689
        10         20         30         40         50         60 
MSYSCCLPSL GCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 

        70         80         90        100        110        120 
QFLNDRLASY LEKVRQLERD NAELEKLIQE RSQQQEPLLC PSYQSYFKTI EELQQKILCA 

       130        140        150        160        170        180 
KAENARLVVN IDNAKLASDD FRSKYQTEQS LRLLVESDIN SIRRILDELT LCKSDLESQV 

       190        200        210        220        230        240 
ESLREELICL KKNHEEEVNT LRSPLGDRLN VEVDTAPTVD LNQVLNETRS QYEALVEINR 

       250        260        270        280        290        300 
REVEQWFATQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 

       310        320        330        340        350        360 
TESEAHYSSQ LSQVQSLITN VESQLAEIRC DLERQNQEYQ VLLDVRARLE CEINTYRSLL 

       370        380        390 
ESEDCKLPCN PCATTNASGN SCGPCGTSQK GCCN

« Hide

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References

[1]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Y16790 Genomic DNA. Translation: CAA76386.1.
UniGeneHs.296942

3D structure databases

HSSPHSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBaseSearch...

Protein-protein interaction databases

IntActO76011. 4 interactions.

Genome annotation databases

EnsemblENSG00000131737. Homo sapiens. [Contig view]

Organism-specific databases

GeneCardsGC17M036788.
HGNCHGNC:6452. KRT34.
MIM602763. gene.
PharmGKBPA30241.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO76011.

Gene expression databases

ArrayExpressO76011.
CleanExHS_KRT34.
GermOnlineENSG00000131737. Homo sapiens.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. IF. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameKRT34_HUMAN
AccessionPrimary (citable) accession number: O76011
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: December 16, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents