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Reviewed, UniProtKB/Swiss-Prot O76071 (CIAO1_HUMAN)

Last modified December 16, 2008. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein CIAO1
Alternative name(s):
    WD repeat-containing protein 39
Gene names
Name: CIAO1
Synonyms: WDR39
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Seems to specifically modulate the transactivation activity of WT1.

Subunit structure

Interacts with WT1.

Subcellular location

Nucleus.

Miscellaneous

'Ciao' means 'bridge' in Chinese.

Sequence similarities

Belongs to the WD repeat CIA1 family.

Contains 7 WD repeats.

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Ontologies

Keywords

   Cellular componentNucleus
   DomainRepeat
WD repeat

Gene Ontology (GO)

   Biological processpositive regulation of cell proliferation Ref.1

Traceable author statement. Source: ProtInc

regulation of transcription from RNA polymerase II promoter Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Protein CIAO1
PRO_0000051389

Regions

Repeat14 – 5340WD 1
Repeat59 – 9840WD 2
Repeat103 – 14240WD 3
Repeat148 – 18740WD 4
Repeat192 – 23140WD 5
Repeat250 – 28940WD 6
Repeat301 – 33838WD 7

Experimental info

Sequence conflict2431C → G in BAD96977. Ref.5

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Sequences

Sequence LengthMass (Da)Tools
O76071-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 63A8D8257A204FC8

FASTA33937,840
        10         20         30         40         50         60 
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH 

        70         80         90        100        110        120 
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 

       130        140        150        160        170        180 
ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT QDVKHVVWHP SQELLASASY DDTVKLYREE 

       190        200        210        220        230        240 
EDDWVCCATL EGHESTVWSL AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS 

       250        260        270        280        290        300 
WKCICTLSGF HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ 

       310        320        330 
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL

« Hide

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References

« Hide 'large scale' references
[1]"Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1."
Johnstone R.W., Wang J., Tommerup N., Vissing H., Roberts T., Shi Y.
J. Biol. Chem. 273:10880-10887(1998) [PubMed: 9556563] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."
Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.
Nat. Cell Biol. 8:1277-1283(2006) [PubMed: 17041588] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.
Genomics 60:295-308(1999) [PubMed: 10493829] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastric mucosa.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood and Skin.
[7]"Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1."
Johnstone R.W., Tommerup N., Hansen C., Vissing H., Shi Y.
Immunogenetics 49:900-905(1999) [PubMed: 10438340] [Abstract]
Cited for: CHARACTERIZATION.

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Cross-references

Sequence databases

U63810 mRNA. Translation: AAC24948.1.
EF011618 mRNA. Translation: ABK41108.1.
AC004020 Genomic DNA. Translation: AAC23493.1.
CR456802 mRNA. Translation: CAG33083.1.
AK223257 mRNA. Translation: BAD96977.1. Different initiation.
BC001395 mRNA. Translation: AAH01395.1.
BC032812 mRNA. Translation: AAH32812.1.
RefSeqNP_004795.1.
UniGeneHs.12109

3D structure databases

HSSPHSSP built from PDB template 1ERJ based on UniProtKB P16649.
ModBaseSearch...

Protein-protein interaction databases

IntActO76071. 53 interactions.

Proteomic databases

PeptideAtlasO76071.
PRIDEO76071.

Genome annotation databases

EnsemblENSG00000144021. Homo sapiens. [Contig view]
GeneID9391.
KEGGhsa:9391.

Organism-specific databases

GeneCardsGC02P096353.
H-InvDBHIX0002272.
HGNCHGNC:14280. CIAO1.
HPAHPA017882.
MIM604333. gene.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO76071.

Gene expression databases

ArrayExpressO76071.
CleanExHS_CIAO1.
GermOnlineENSG00000144021. Homo sapiens.

Family and domain databases

InterProIPR015943. WD40/YVTN_repeat-like.
IPR001680. WD40_repeat.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
ProDomPD000018. WD40. 5 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio35187.
SOURCESearch...

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Entry information

Entry nameCIAO1_HUMAN
AccessionPrimary (citable) accession number: O76071
Secondary accession number(s): A0MNN9, Q53FM5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: December 16, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents