Pyruvate phosphate dikinase - Trypanosoma brucei

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Unreviewed, UniProtKB/TrEMBL O76283 (O76283_9TRYP)

Last modified September 2, 2008. Version 44. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Pyruvate phosphate dikinase EMBL AAC39128.2

Gene names

Name:

PPDK EMBL AAC39128.2

Organism

Trypanosoma brucei EMBL AAC39128.2

Taxonomic identifier

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro kinase activity Inferred from electronic annotation. Source: InterPro pyruvate, phosphate dikinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

O76283-1 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: E886276BC678BFB7
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913

100,408

        10         20         30         40         50         60 
MVAKKWVYYF GGGNADGNKN MKELLGGKGA NLAEMVNLGI PVPPGFTITT EACKTYQETE 

        70         80         90        100        110        120 
TIPQEVADQV RENVSRVEKE MGAKFGDPAN PLLFSVRSGA AASMPGMMDT VLNLGLNKVT 

       130        140        150        160        170        180 
VDAWVRRAPR LERFVYDSYR RFITMYADIV MQVGREDFEE ALSRMKERRG TKFDTDLTAS 

       190        200        210        220        230        240 
DLKELCDGYL ELFELKTGCS FPQDPVMQLF AAIKAVFRSW GNPRATIYRR MNNITGLLGT 

       250        260        270        280        290        300 
AVNVQAMVFG NINDRSATGV AFSRSPSTGE NFFFGEYLVN AQGEDVVAGI RTPQQINHSL 

       310        320        330        340        350        360 
SLRWAKAHGV GEEERRKRYP SMEEAMPENY RLLCDVRKRL ENHYRDMQDL EFTVQDGRLW 

       370        380        390        400        410        420 
LLQCRNGKRT IHAAVRIAID MVNEGLISRE EAVLRIDPYQ VDHLMHPNLE PGAEKANKPI 

       430        440        450        460        470        480 
GRGLAASPGA AVGQVVFDAE SAKEWSGRGK KVIMVRLETS PEDLAGMDAA CGILTARGGM 

       490        500        510        520        530        540 
TSHAAVVARG MGKCCVSGCG DMVIRGKSFK LNGSVFREGD YITIDGSKGL IYAGKLKLRS 

       550        560        570        580        590        600 
PDLKGSFQTI LQWCQEMKRL GVRTNADTPA DAAKARSFGA EGVGLCRTEH MFFEGSRINF 

       610        620        630        640        650        660 
IREMILADSA SGRKAALDKL LPIQRADFVG ILRAMRGLPV TIRLLDPPLH EFVPHDAAAQ 

       670        680        690        700        710        720 
FELAQKLGMP AEKVRNRVNA LHELNPMLGH RGCRLGITYP EIYNMQVRAI IEAAIAVSEE 

       730        740        750        760        770        780 
GSSVIPEIMV PLVGKKEELS LIREEVVKTA EAVITKSGKR VHYTVGTMIE VPRAAVTADS 

       790        800        810        820        830        840 
IAQKADFFSF GTNDLTQMGC GFSRDDAGPF LRHYGNLGIY AQDPFQSIDQ EGIGELVRIA 

       850        860        870        880        890        900 
VTKGRRVKPM LKMGICGEHG GDPATIGFCH KVGLDYVSCS PFRVPVAIVA AAHASIKDRR 

       910 
AAMKARKGFA AKL

References

[1]	"Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase." Bringaud F., Baltz D., Baltz T. Proc. Natl. Acad. Sci. U.S.A. 95:7963-7968(1998) [PubMed: 9653123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: AnTat1 EMBL AAC39128.2.
[2]	Bringaud F., Baltz D., Baltz T. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: AnTat1 EMBL AAC39128.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases

AF048689 Genomic DNA. Translation: AAC39128.2.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1H6Z	X-ray	3.00	A	1-913	[»]

ModBase

Family and domain databases

InterPro

IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR008279. PEP_mobile.
IPR000121. PEP_utilizers.
IPR002192. PPDK_PEP_bd.
IPR010121. Pyruvate_phosphate_dikinase.
IPR015813. Pyrv/PenolPyrv_Kinase_cat.
[Graphical view]

Gene3D

G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.50.30.10. PEP_mobile. 1 hit.
G3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit.

Pfam

PF00391. PEP-utilizers. 1 hit.
PF02896. PEP-utilizers_C. 1 hit.
PF01326. PPDK_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000853. PPDK. 1 hit.

ProDom

PD000940. PEP_utilizers. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01828. pyru_phos_dikin. 1 hit.

PROSITE

PS00370. PEP_ENZYMES_PHOS_SITE. 1 hit.
[Graphical view]

Entry information

Entry name

O76283_9TRYP

Accession

Primary (citable) accession number: O76283

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	October 1, 2001
Last modified:	September 2, 2008
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information