Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot O89343 (GLYCP_HENDV)

Last modified November 25, 2008. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Glycoprotein G
Gene names
Name: G
OrganismHendra virus
Taxonomic identifier63330 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Henipavirus
Virus hostPteropus alecto (Black flying fox) [TaxID: 9402]
Pteropus poliocephalus (Grey-headed flying fox) [TaxID: 9403]
Homo sapiens (Human) [TaxID: 9606]
Equus caballus (Horse) [TaxID: 9796]
Pteropus scapulatus (Little red flying fox) [TaxID: 94117]

Hide | Top

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of glycoprotein G to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Subcellular location

Virion membrane; Single-pass type II membrane proteinPotential. Cell membrane; Single-pass type II membrane proteinPotential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Caution

Henipavirus glycoproteins have no neuraminidase activity.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 604604Glycoprotein G
PRO_0000236008

Regions

Topological domain1 – 4949Cytoplasmic Potential
Transmembrane50 – 7021 Potential
Topological domain71 – 604534Extracellular Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential
Glycosylation5291N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O89343-1 [UniParc].

Last modified June 1, 2003. Version 2.
Checksum: E2FA826A8ED5BE4D

FASTA60467,191
        10         20         30         40         50         60 
MMADSKLVSL NNNLSGKIKD QGKVIKNYYG TMDIKKINDG LLDSKILGAF NTVIALLGSI 

        70         80         90        100        110        120 
IIIVMNIMII QNYTRTTDNQ ALIKESLQSV QQQIKALTDK IGTEIGPKVS LIDTSSTITI 

       130        140        150        160        170        180 
PANIGLLGSK ISQSTSSINE NVNDKCKFTL PPLKIHECNI SCPNPLPFRE YRPISQGVSD 

       190        200        210        220        230        240 
LVGLPNQICL QKTTSTILKP RLISYTLPIN TREGVCITDP LLAVDNGFFA YSHLEKIGSC 

       250        260        270        280        290        300 
TRGIAKQRII GVGEVLDRGD KVPSMFMTNV WTPPNPSTIH HCSSTYHEDF YYTLCAVSHV 

       310        320        330        340        350        360 
GDPILNSTSW TESLSLIRLA VRPKSDSGDY NQKYIAITKV ERGKYDKVMP YGPSGIKQGD 

       370        380        390        400        410        420 
TLYFPAVGFL PRTEFQYNDS NCPIIHCKYS KAENCRLSMG VNSKSHYILR SGLLKYNLSL 

       430        440        450        460        470        480 
GGDIILQFIE IADNRLTIGS PSKIYNSLGQ PVFYQASYSW DTMIKLGDVD TVDPLRVQWR 

       490        500        510        520        530        540 
NNSVISRPGQ SQCPRFNVCP EVCWEGTYND AFLIDRLNWV SAGVYLNSNQ TAENPVFAVF 

       550        560        570        580        590        600 
KDNEILYQVP LAEDDTNAQK TITDCFLLEN VIWCISLVEI YDTGDSVIRP KLFAVKIPAQ 


CSES

« Hide

Hide | Top

References

[1]"The attachment protein of Hendra virus has high structural similarity but limited primary sequence homology compared with viruses in the genus Paramyxovirus."
Yu M., Hansson E., Langedijk J.P., Eaton B.T., Wang L.F.
Virology 251:227-233(1998) [PubMed: 9837786] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Hide | Top

Cross-references

Sequence databases

AF017149 Genomic RNA. Translation: AAC83193.2.
PIRT08211.
RefSeqNP_047112.2.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2VSKX-ray3.30A/C188-603[»]
ModBaseSearch...

Genome annotation databases

GeneID1446471.

Family and domain databases

InterProIPR000665. Hemagglutn-neuramid_glycoprot.
IPR016285. Hemagglutn-neuramid_paramyxo.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry nameGLYCP_HENDV
AccessionPrimary (citable) accession number: O89343
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: November 25, 2008
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Hide | Top

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents