Reviewed, UniProtKB/Swiss-Prot O93593 (MTA_CHAAC)

Names and origin

Protein names

Recommended name:
    Metallothionein A
      Short name=MT-A

Gene names

Name:

mta

Organism

Chaenocephalus aceratus (White crocodile fish)

Taxonomic identifier

36190 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chaenocephalus

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster Zinc
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 60	60	Metallothionein A
Regions
	Region	1 – 28	28	Beta
	Region	29 – 60	32	Alpha
Sites
	Metal binding	4	1	Cluster B By similarity
	Metal binding	6	1	Cluster B By similarity
	Metal binding	12	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	18	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	23	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	28	1	Cluster B By similarity
	Metal binding	32	1	Cluster A By similarity
	Metal binding	33	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	36	1	Cluster A By similarity
	Metal binding	40	1	Cluster A By similarity
	Metal binding	43	1	Cluster A By similarity
	Metal binding	47	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	54	1	Cluster A By similarity
	Metal binding	58	1	Cluster A By similarity
	Metal binding	59	1	Cluster A By similarity

Sequences

	Sequence		Length	Mass (Da)
	O93593-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E8773344264C424A	FASTA	60	6,017
	10 20 30 40 50 60 MDPCECSKSG NCNCGGSCTC TNCSCKSCKK SCCPCCPSGC TKCASGCVCI GKTCDTSCCQ

References

[1]	"Metallothioneins in antarctic fish: evidence for independent duplication and gene conversion." Bargelloni L., Scudiero R., Parisi E., Carginale V., Capasso C., Patarnello T. Mol. Biol. Evol. 16:885-897(1999) [PubMed: 10406107] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ011583 mRNA. Translation: CAA09713.1.
3D structure databases
HSSP	HSSP built from PDB template 1M0G based on UniProtKB O73914.
ModBase	Search...
Phylogenomic databases
HOVERGEN	O93593.
Family and domain databases
InterPro	IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	O93593. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MTA_CHAAC

Accession

Primary (citable) accession number: O93593

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1998
Last modified:	July 22, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)