Reviewed, UniProtKB/Swiss-Prot O93853 (AOX1_CANAL)

Names and origin

Protein names

Recommended name:
    Alternative oxidase 1, mitochondrial
    EC=1.-.-.-

Gene names

Name:	AOX1
Synonyms:	AOX1A

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures By similarity.
Cofactor	Binds 2 iron ions per subunit By similarity.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein; Matrix sideBy similarity. Note= Possibly in the inner surface of the inner mitochondrial membrane By similarity.
Sequence similarities	Belongs to the alternative oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW respiratory gaseous exchange Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 379		Alternative oxidase 1, mitochondrial		PRO_0000001717
Regions
	Transmembrane	234 – 256	23	Potential
Sites
	Metal binding	180	1	Iron Potential
	Metal binding	219	1	Iron Potential
	Metal binding	222	1	Iron Potential
	Metal binding	271	1	Iron Potential
	Metal binding	326	1	Iron Potential
	Metal binding	329	1	Iron Potential

Sequences

	Sequence		Length	Mass (Da)
	O93853-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C2DDC2CA298BD0F9	FASTA	379	43,975
	10 20 30 40 50 60 MIGLSTYRNL PTLLTTTTVI STALRSKQLL RFTTTTSTKS RSSTSTAATT VGNSNPKSPI 70 80 90 100 110 120 DEDNLEKPGT IPTKHKPFNI QTEVYNKAGI EANDDDKFLT KPTYRHEDFT EAGVYRVHVT 130 140 150 160 170 180 HRPPRTIGDK ISCYGTLFFR KCFDLVTGYA VPDPDKPDQY KGTRWEMTEE KWMTRCIFLE 190 200 210 220 230 240 SIAGVPGSVA GFVRHLHSLR MLTRDKAWIE TLHDEAYNER MHLLTFIKIG KPSWFTRSII 250 260 270 280 290 300 YIGQGVFTNI FFLVYLMNPR YCHRFVGYLE EEAVRTYTHL IDELDDPNKL PDFQKLPIPN 310 320 330 340 350 360 IAVQYWPELT PESSFKDLIL RIRADEAKHR EINHTFANLE QWQDRNPFAL KIKDSDKPQP 370 NYNLDVTRPQ GWERKDLYL

References

[1]	"Molecular cloning and functional expression of alternative oxidase from Candida albicans." Huh W.-K., Kang S.-O. J. Bacteriol. 181:4098-4102(1999) [PubMed: 10383980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10231 / CBS 6431 / DSM 1386 / IFO 1594.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF031229 Genomic DNA. Translation: AAC98914.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR002680. AOX. [Graphical view]
Pfam	PF01786. AOX. 1 hit. [Graphical view]
PIRSF	PIRSF005229. AOX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AOX1_CANAL

Accession

Primary (citable) accession number: O93853

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)