Reviewed, UniProtKB/Swiss-Prot O93869 (GYS_NEUCR)

Names and origin

Protein names

Recommended name:
    Glycogen [starch] synthase
    EC=2.4.1.11

Gene names

ORF Names:

7F4.080, NCU06687

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.
Catalytic activity	UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).
Enzyme regulation	Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase By similarity.
Pathway	Glycan biosynthesis; glycogen biosynthesis.
Sequence similarities	Belongs to the mammalian/fungal glycogen synthase family.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
PTM	Phosphoprotein
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	glycogen biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	glycogen (starch) synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Glycogen [starch] synthase		PRO_0000194772
Sites
	Binding site	26	1	UDP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	O93869-1 [UniParc]. Last modified November 1, 1999. Version 2. Checksum: CDF0DB45549FF4BB	FASTA	706	80,907
	10 20 30 40 50 60 MAHDNREPRE VKNHLLFEVA TEVAHRVGGI YSVLKSKAPV TTAEYGDRYT LIGPLNHQSA 70 80 90 100 110 120 AVEVEELEPS NPELKATIQA MRDRGIGILY GRWLIEGAPR VLLFDTKTAY GYMNEWKTDL 130 140 150 160 170 180 WNVASIPSPD NDEETNEAIV FGYLVAWFLG EFVCHEKRKA VIAHFHEWLA GVALPLTKKR 190 200 210 220 230 240 QIDVTTIFTT HATLLGRYLC AGSVDFYNNL QWFDVDAEAG KRGIYHRYCI ERAAAHSCDV 250 260 270 280 290 300 FTTVSHITAY ESEHLLKRKP DGVLPNGLNV TKFSAMHEFQ NLHQQNKEKI HDFVRGHFYG 310 320 330 340 350 360 HYDFEPENTL YFFTAGRYEF RNKGVDMFIE SLARLNHRLK TAGSKTTVVA FIIMPAQTTS 370 380 390 400 410 420 LTVEALKGQA VIKSLRDTVD VIERGIGRRI FERSVKWHEG DPLPEEKELI TSQDRVLLRR 430 440 450 460 470 480 RLFAMKRHTL PPIVTHNMLN DHEDPILNQI RRVQLFNHPS DRVKIVFHPE FLSSANPVLP 490 500 510 520 530 540 LDYDDFVRGT HLGVFASYYE PWGYTPAECT VMGVPSITTN LSGFGCYMEE LIENSSDYGI 550 560 570 580 590 600 YIVDRRSKGV DDSVNQLTQY MFEFTQKSRR QRINQRNRTE RLSDLLDWKR MGMEYVKARQ 610 620 630 640 650 660 LALRRAYPTS FNGEEEEDFI PGVEQKISRP FSVPGSPRDR TGMMTPGDFA SLQESHEGLS 670 680 690 700 TEDYVAWKLP EEEDPEEYPF PLTLKQRTGP GSPLDSIQGL QLNGTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	de Paula R., Terenzi H.F., Bertolini M.C. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF056080 mRNA. Translation: AAC98780.2. BX294020 Genomic DNA. Translation: CAD70912.1. AABX02000031 Genomic DNA. Translation: EAA31766.1.
RefSeq	XP_961002.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3877149.
KEGG	ncr:NCU06687.
NMPDR	fig|5141.1.peg.4906.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-001546-MON.
Family and domain databases
InterPro	IPR008631. Glycogen_synth. [Graphical view]
PANTHER	PTHR10176. Glycogen_synth. 1 hit.
Pfam	PF05693. Glycogen_syn. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYS_NEUCR

Accession

Primary (citable) accession number: O93869
Secondary accession number(s): Q7S7N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1999
Last modified:	November 25, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)