Reviewed, UniProtKB/Swiss-Prot O94038 (ADH2_CANAL)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1

Gene names

Name:	ADH2
ORF Names:	Ca41C10.04

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Alcohol dehydrogenase 2		PRO_0000160718
Sites
	Metal binding	44	1	Zinc 1; catalytic By similarity
	Metal binding	67	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	154	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94038-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3D6E67538522ADCF	FASTA	348	36,807
	10 20 30 40 50 60 MSVPTTQKAV IFETNGGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA WKGDWPLATK 70 80 90 100 110 120 LPLVGGHEGA GVVVALGENV KGWKVGDYAG VKWLNGSCLN CEYCQSGAEP NCAEADLSGY 130 140 150 160 170 180 THDGSFQQYA TADAVQAARI PAGTDLANVA PILCAGVTVY KALKTAELEA GQWVAISGAA 190 200 210 220 230 240 GGLGSLAVQY AKAMGYRVLA IDGGEDKGEF VKSLGAETFI DFTKEKDVVE AVKKATNGGP 250 260 270 280 290 300 HGVINVSVSE RAIGQSTEYV RTLGKVVLVG LPAGAKISTP VFDAVIKTIQ IKGSYVGNRK 310 320 330 340 DTAEAVDFFT RGLIKCPIKI VGLSELPEVY KLMEEGKILG RYVLDNDK

References

[1]	"Candida albicans strain 1161 genome pilot sequencing project." Taylor K., Harris D., Barrell B.G., Rajandream M.A. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1161.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL033501 Genomic DNA. Translation: CAA21988.1.
PIR	T18230.
3D structure databases
HSSP	HSSP built from PDB template 1JVB based on UniProtKB P39462.
SMR	O94038. Positions 2-348.
ModBase	Search...
Organism-specific databases
CGD	CAL0002509. ADH2.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_CANAL

Accession

Primary (citable) accession number: O94038

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)