Reviewed, UniProtKB/Swiss-Prot O94049 (ACS1_CANAL)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase 1
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase 1
    Acyl-activating enzyme 1

Gene names

Name:	ACS1
ORF Names:	Ca38F10.03

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Molecular function	Ligase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro acetate-CoA ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 675	675	Acetyl-coenzyme A synthetase 1		PRO_0000208405
Natural variations
	Natural variant	504	1	N → K
	Natural variant	543	1	N → D

Sequences

	Sequence		Length	Mass (Da)
	O94049-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 32CD1F462F789B90	FASTA	675	75,100
	10 20 30 40 50 60 MPESTQQSHL SLDHEKMQQP PKGFTERSKT KPNLADFETY QKLYKQSIEN PNEFFTQQAK 70 80 90 100 110 120 ENLDWFKPFD LARFPVDPKD DYKNGDLPAW FINGQLNACY NAVDRWAIKN PDKPAIIYEG 130 140 150 160 170 180 DEPDQGRIIT YGELLKQVSK LAQALTKLGV KKGDSVAVYL PMIPEAIVTL LAIVRIGAMH 190 200 210 220 230 240 SVVFAGFSSA SLRDRILDAD SRIVITADES KRGGKTIETK KIVDDALKEC PKVRNVIVFK 250 260 270 280 290 300 RTGNSHVPFS PGRDLWWHDE MAKYGPYFPP VPVNSEDPLF LLYTSGSTGK PKGVQHNTAG 310 320 330 340 350 360 YLLGAVLTTK YTFDVHEDDI LFTAGDIGWI TGHTYCVYGP LLAGATSVVF EGTPAYPNYS 370 380 390 400 410 420 RYWEIVDKYK VNQFYVAPTA LRLLKRAGTK YVEKYDLSSL RVLGSVGEPI AAEVWHWYND 430 440 450 460 470 480 NIGRGQAHIV DTYWQTESGS HLLTPLAGIT PTKPGSASLP FFGVDPKILD PTTGEELPDN 490 500 510 520 530 540 DVEGVLAIKS AWPSITRGIY NDYNRFIDTY LAPYANYYFS GDGAARDRDG FYWILGRVDD 550 560 570 580 590 600 VVNVSGHRLS TAEIEAALIE HPIVGESAVV GYADELTGQA VAAYVSLKKD KAVGEDVENI 610 620 630 640 650 660 KKEMILTVRK EIGPFAAPKM ILLVDDLPKT RSGKIMRRIL RKVLAGEEDQ LGDISTLSNP 670 GVVQQIIDVV HHAKK

References

[1]	"Candida albicans strain 1161 genome pilot sequencing project." Oliver K., Harris D., Barrell B.G., Rajandream M.A. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1161.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL033502 Genomic DNA. Translation: CAA22000.1.
3D structure databases
HSSP	HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6.
ModBase	Search...
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PRINTS	PR00154. AMPBINDING.
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS1_CANAL

Accession

Primary (citable) accession number: O94049

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)