Reviewed, UniProtKB/Swiss-Prot O95190 (OAZ2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase antizyme 2
      Short name=ODC-Az 2
      Short name=AZ2

Gene names

Name:

OAZ2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration By similarity.
Sequence similarities	Belongs to the ODC antizyme family.

Ontologies

Keywords
Coding sequence diversity	Ribosomal frameshifting
Gene Ontology (GO)
Biological process	polyamine metabolic process Traceable author statement. Source: ProtInc
Molecular function	ornithine decarboxylase inhibitor activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AZIN1	O14977	1	EBI-1051861,EBI-1054824
ODC1	P11926	1	EBI-1051861,EBI-1044287

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Notes: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

Isoform 1 (identifier: O95190-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Ornithine decarboxylase antizyme 2		PRO_0000220857

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 66390D87EB30CB8F	FASTA	189	21,011
	10 20 30 40 50 60 MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD 70 80 90 100 110 120 EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL 130 140 150 160 170 180 ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED

References

[1]	"A second mammalian antizyme: conservation of programmed ribosomal frameshifting." Ivanov I.P., Gesteland R.F., Atkins J.F. Genomics 52:119-129(1998) [PubMed: 9782076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of human ornithine decarboxylase antizyme 2 gene." Zhou J., Atkins J.F., Gesteland R.F. Gene 232:165-171(1999) [PubMed: 10352227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF057297 mRNA. Translation: AAD03265.1.
RefSeq	NP_002528.1.
UniGene	Hs.352225 Hs.643010 Hs.74563
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95190.
PTM databases
PhosphoSite	O95190.
Genome annotation databases
Ensembl	ENSG00000180304. Homo sapiens. [Contig view]
GeneID	4947.
KEGG	hsa:4947.
Organism-specific databases
H-InvDB	HIX0026777.
HGNC	HGNC:8096. OAZ2.
MIM	604152. gene.
PharmGKB	PA31885.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O95190.
HOVERGEN	O95190.
Gene expression databases
ArrayExpress	O95190.
CleanEx	HS_OAZ2.
GermOnline	ENSG00000180304. Homo sapiens.
Family and domain databases
InterPro	IPR002993. ODC_AZ. [Graphical view]
PANTHER	PTHR10279. ODC_AZ. 1 hit.
Pfam	PF02100. ODC_AZ. 1 hit. [Graphical view]
ProDom	PD007483. ODC_AZ. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01337. ODC_AZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00129. L-Ornithine.
LinkHub	O95190.
NextBio	19057.
SOURCE	Search...

Entry information

Entry name

OAZ2_HUMAN

Accession

Primary (citable) accession number: O95190

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)