CD2 antigen cytoplasmic tail-binding protein 2

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Reviewed, UniProtKB/Swiss-Prot O95400 (CD2B2_HUMAN)

Last modified December 16, 2008. Version 66. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    CD2 antigen cytoplasmic tail-binding protein 2
Alternative name(s):
    CD2 cytoplasmic domain-binding protein
    CD2 tail-binding protein
    CD_antigen=CD2

Gene names

Name:	CD2BP2
Synonyms:	KIAA1178

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subunit structure	Binds the cytoplasmic domain of CD2 through the GYF domain.
Subcellular location	Cytoplasm.
Sequence similarities	Contains 1 GYF domain.

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Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	nuclear mRNA splicing, via spliceosome Inferred from Experiment. Source: Reactome
Cellular component	cytoplasm Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
ASCC3L1	O75643	1	EBI-768015,EBI-1045395
C5orf41	Q8IUR6	1	EBI-768015,EBI-1042699
CMBL	Q96DG6	1	EBI-768015,EBI-1044268
DCD	P81605	1	EBI-768015,EBI-395625
DDX23	Q9BUQ8	1	EBI-768015,EBI-540096
EFTUD2	Q15029	1	EBI-768015,EBI-357897
EWSR1	Q01844	1	EBI-768015,EBI-739737
KHK	P50053	1	EBI-768015,EBI-1053974
NUDT21	O43809	1	EBI-768015,EBI-355720
P4HB	P07237	1	EBI-768015,EBI-395883
PRPF6	O94906	1	EBI-768015,EBI-536755
PRPF8	Q6P2Q9	1	EBI-768015,EBI-538479
PRPSAP1	Q14558	1	EBI-768015,EBI-724449
PUF60	Q9UHX1	1	EBI-768015,EBI-1053259
SNRPF	P62306	1	EBI-768015,EBI-356900
SNRPG	P62308	1	EBI-768015,EBI-624585
USP39	Q53GS9	1	EBI-768015,EBI-1044822
WDR57	Q96DI7	1	EBI-768015,EBI-538492

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 341

341

CD2 antigen cytoplasmic tail-binding protein 2

PRO_0000089437

Regions

Domain

280 – 338

GYF

Amino acid modifications

Modified residue

Phosphoserine Ref.4 Ref.6 Ref.7 Ref.9

Modified residue

118

Phosphoserine Ref.8

Modified residue

195

Phosphoserine Ref.4 Ref.5

Natural variations

Natural variant

231

G → D: dbSNP rs13330462.

VAR_050772

Natural variant

262

T → I: dbSNP rs34391305.

VAR_050773

Secondary structure

341

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

O95400-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 8E9A7EE0C40474D5
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FASTA

341

37,646

        10         20         30         40         50         60 
MPKRKVTFQG VGDEEDEDEI IVPKKKLVDP VAGSGGPGSR FKGKHSLDSD EEEDDDDGGS 

        70         80         90        100        110        120 
SKYDILASED VEGQEAATLP SEGGVRITPF NLQEEMEEGH FDADGNYFLN RDAQIRDSWL 

       130        140        150        160        170        180 
DNIDWVKIRE RPPGQRQASD SEEEDSLGQT SMSAQALLEG LLELLLPRET VAGALRRLGA 

       190        200        210        220        230        240 
RGGGKGRKGP GQPSSPQRLD RLSGLADQMV ARGNLGVYQE TRERLAMRLK GLGCQTLGPH 

       250        260        270        280        290        300 
NPTPPPSLDM FAEELAEEEL ETPTPTQRGE AESRGDGLVD VMWEYKWENT GDAELYGPFT 

       310        320        330        340 
SAQMQTWVSE GYFPDGVYCR KLDPPGGQFY NSKRIDFDLY T

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation." Nishizawa K., Freund C., Li J., Wagner G., Reinherz E.L. Proc. Natl. Acad. Sci. U.S.A. 95:14897-14902(1998) [PubMed: 9843987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-341. Tissue: Brain.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-195, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction." Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R. Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed: 17693683] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, MASS SPECTROMETRY.
[7]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, MASS SPECTROMETRY.
[9]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, MASS SPECTROMETRY. Tissue: Liver.
[10]	"The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences." Freund C., Dotsch V., Nishizawa K., Reinherz E.L., Wagner G. Nat. Struct. Biol. 6:656-660(1999) [PubMed: 10404223] [Abstract] Cited for: STRUCTURE BY NMR OF 280-341.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AF104222 mRNA. Translation: AAC84141.1.
BC000495 mRNA. Translation: AAH00495.1.
BC001947 mRNA. Translation: AAH01947.1.
AB033004 mRNA. Translation: BAA86492.1.

RefSeq

NP_006101.1.

UniGene

Hs.700708

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GYF	NMR	-	A	280-341	[»]
1L2Z	NMR	-	A	280-341	[»]
1SYX	X-ray	2.35	B/D/F	256-341	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O95400. 27 interactions.

PTM databases

PhosphoSite

O95400.

Proteomic databases

PRIDE

O95400.

Genome annotation databases

Ensembl

ENSG00000169217. Homo sapiens. [Contig view]

GeneID

10421.

KEGG

hsa:10421.

Organism-specific databases

GeneCards

GC16M030272.

H-InvDB

HIX0012951.

HGNC

HGNC:1656. CD2BP2.

MIM

604470. gene.

PharmGKB

PA26209.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOGENOM

O95400.

HOVERGEN

O95400.

Enzyme and pathway databases

Reactome

REACT_1675. mRNA Processing.
REACT_6167. Influenza Infection.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

O95400.

CleanEx

HS_CD2BP2.

GermOnline

ENSG00000169217. Homo sapiens.

Family and domain databases

InterPro

IPR003169. GYF.
[Graphical view]

Pfam

PF02213. GYF. 1 hit.
[Graphical view]

SMART

SM00444. GYF. 1 hit.
[Graphical view]

PROSITE

PS50829. GYF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

LinkHub

O95400.

NextBio

39496.

SOURCE

Search...

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Entry information

Entry name

CD2B2_HUMAN

Accession

Primary (citable) accession number: O95400
Secondary accession number(s): Q9ULP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 1, 1999
Last modified:	December 16, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents