BAG family molecular chaperone regulator 4

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Reviewed, UniProtKB/Swiss-Prot O95429 (BAG4_HUMAN)

Last modified July 22, 2008. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    BAG family molecular chaperone regulator 4
      Short name=BAG-4
Alternative name(s):
    Bcl-2-associated athanogene 4
    Silencer of death domains

Gene names

Name:	BAG4
Synonyms:	SODD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release By similarity. Prevents constitutive TNFRSF1A signaling.
Subunit structure	Binds to the ATPase domain of HSP70/HSC chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12.
Subcellular location	Cytoplasm.
Tissue specificity	Ubiquitous.
Sequence similarities	Contains 1 BAG domain.

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Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	3D-structure
Gene Ontology (GO)
Biological process	anti-apoptosis Ref.2 Traceable author statement. Source: ProtInc protein folding Ref.1 Traceable author statement. Source: ProtInc
Molecular function	receptor signaling protein activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 457

457

BAG family molecular chaperone regulator 4

Regions

Domain

379 – 456

BAG

Experimental info

Mutagenesis

414

E → A: Reduces interaction with HSP70

Mutagenesis

424

D → A: Abolishes interaction with HSP70

Mutagenesis

438 – 439

RK → AA: Reduces interaction with HSP70

Mutagenesis

446

Q → A: Abolishes interaction with HSP70

Secondary structure

457

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

O95429-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B89D59E8118684A3
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FASTA

457

49,594

        10         20         30         40         50         60 
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET 

        70         80         90        100        110        120 
TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS NYWNSTARSR APYPSTYPVR 

       130        140        150        160        170        180 
PELQGQSLNS YTNGAYGPTY PPGPGANTAS YSGAYYAPGY TQTSYSTEVP STYRSSGNSP 

       190        200        210        220        230        240 
TPVSRWIYPQ QDCQTEAPPL RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE 

       250        260        270        280        290        300 
DAWASPGAYG MGGRYPWPSS APSAPPGNLY MTESTSPWPS SGSPQSPPSP PVQQPKDSSY 

       310        320        330        340        350        360 
PYSQSDQSMN RHNFPCSVHQ YESSGTVNND DSDLLDSQVQ YSAEPQLYGN ATSDHPNNQD 

       370        380        390        400        410        420 
QSSSLPEECV PSDESTPPSI KKIIHVLEKV QYLEQEVEEF VGKKTDKAYW LLEEMLTKEL 

       430        440        450 
LELDSVETGG QDSVRQARKE AVCKIQAILE KLEKKGL

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." Takayama S., Xie Z., Reed J.C. J. Biol. Chem. 274:781-786(1999) [PubMed: 9873016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leukemic T-cell.
[2]	"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains." Jiang Y., Woronicz J.D., Liu W., Goeddel D.V. Science 283:543-546(1999) [PubMed: 9915703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TNFRSF1A AND TNFRSF12. Tissue: Leukemic T-cell.
[3]	Erratum Jiang Y., Woronicz J.D., Liu W., Goeddel D.V. Science 283:1852-1852(1999)
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"BAG4/SODD protein contains a short BAG domain." Briknarova K., Takayama S., Homma S., Baker K., Cabezas E., Hoyt D.W., Li Z., Satterthwait A.C., Ely K.R. J. Biol. Chem. 277:31172-31178(2002) [PubMed: 12058034] [Abstract] Cited for: STRUCTURE BY NMR OF 376-457, INTERACTION WITH HSP70, MUTAGENESIS OF GLU-414; ASP-424; 438-ARG-LYS-439 AND GLN-446.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AF095194 mRNA. Translation: AAD16123.2.
AF111116 mRNA. Translation: AAD05226.1.
BC038505 mRNA. Translation: AAH38505.2.

RefSeq

NP_004865.1.

UniGene

Hs.194726

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1M62	NMR	-	A	372-457	[»]
1M7K	NMR	-	A	358-456	[»]

SMR

O95429. Positions 372-457.

ModBase

Search...

PTM databases

PhosphoSite

O95429.

Genome annotation databases

Ensembl

ENSG00000156735. Homo sapiens. [Contig view]

GeneID

9530.

KEGG

hsa:9530.

Organism-specific databases

H-InvDB

HIX0020972.

HGNC

HGNC:940. BAG4.

HPA

CAB013716.

MIM

603884. gene.

PharmGKB

PA25240.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

O95429.

HOVERGEN

O95429.

Gene expression databases

ArrayExpress

O95429.

CleanEx

HS_BAG4.

GermOnline

ENSG00000156735. Homo sapiens.

Family and domain databases

InterPro

IPR003103. BAG.
[Graphical view]

Pfam

PF02179. BAG. 1 hit.
[Graphical view]

SMART

SM00264. BAG. 1 hit.
[Graphical view]

PROSITE

PS51035. BAG. 1 hit.
[Graphical view]

ProDom

O95429.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

LinkHub

O95429.

SOURCE

Search...

ProtoNet

Search...

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Entry information

Entry name

BAG4_HUMAN

Accession

Primary (citable) accession number: O95429
Secondary accession number(s): O95818

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	July 22, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents