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Reviewed, UniProtKB/Swiss-Prot O95622 (ADCY5_HUMAN)

Last modified November 25, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 5
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type V
    ATP pyrophosphate-lyase 5
    Adenylyl cyclase 5
Gene names
Name: ADCY5
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Inhibition by calcium in the submicromolar concentration range By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

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Ontologies

Keywords

   Biological processcAMP biosynthesis
   Cellular componentMembrane
   DomainRepeat
Transmembrane
   LigandMagnesium
Metal-binding
   Molecular functionLyase
   PTMGlycoprotein
Phosphoprotein

Gene Ontology (GO)

   Biological processcAMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular signaling cascade

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenylate cyclase activity

Inferred from electronic annotation. Source: InterPro

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12611261Adenylate cyclase type 5
PRO_0000195694

Regions

Topological domain1 – 195195Cytoplasmic Potential
Transmembrane196 – 21621 Potential
Transmembrane242 – 26221 Potential
Transmembrane268 – 28821 Potential
Transmembrane299 – 31921 Potential
Transmembrane325 – 34521 Potential
Transmembrane349 – 36921 Potential
Transmembrane374 – 39421 Potential
Topological domain395 – 769375Cytoplasmic Potential
Transmembrane770 – 79021 Potential
Transmembrane792 – 81221 Potential
Transmembrane836 – 85621 Potential
Topological domain857 – 90953Extracellular Potential
Transmembrane910 – 93021 Potential
Transmembrane935 – 95521 Potential
Transmembrane984 – 100421 Potential
Topological domain1005 – 1261257Cytoplasmic Potential
Domain469 – 596128Guanylate cyclase 1
Domain1071 – 1210140Guanylate cyclase 2

Sites

Metal binding4741Magnesium 1 By similarity
Metal binding4741Magnesium 2 By similarity
Metal binding4751Magnesium 2; via carbonyl oxygen By similarity
Metal binding5181Magnesium 1 By similarity
Metal binding5181Magnesium 2 By similarity

Amino acid modifications

Modified residue81Phosphoserine By similarity
Glycosylation8701N-linked (GlcNAc...) Potential
Glycosylation8871N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
O95622-1 [UniParc].

Last modified November 28, 2006. Version 3.
Checksum: C50492A0B053694F

FASTA1,261138,908
        10         20         30         40         50         60 
MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA 

        70         80         90        100        110        120 
VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK SAWQERGGDD CGRGSRRQRR 

       130        140        150        160        170        180 
GAASGGSTRA PPAGGGGGSA AAAASAGGTE VRPRSVEVGL EERRGKGRAA DELEAGAVEG 

       190        200        210        220        230        240 
GEGSGDGGSS ADSGSGAGPG AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS 

       250        260        270        280        290        300 
SLTMLMAVLV LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL 

       310        320        330        340        350        360 
ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA VLSGVLLSAL 

       370        380        390        400        410        420 
HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA EVSQRQAFQE TRECIQARLH 

       430        440        450        460        470        480 
SQRENQQQER LLLSVLPRHV AMEMKADINA KQEDMMFHKI YIQKHDNVSI LFADIEGFTS 

       490        500        510        520        530        540 
LASQCTAQEL VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM 

       550        560        570        580        590        600 
GMDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK 

       610        620        630        640        650        660 
AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK EEKAMIAKMN 

       670        680        690        700        710        720 
RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED PKDKNAQESA NPEDEVDEFL 

       730        740        750        760        770        780 
GRAIDARSID RLRSEHVRKF LLTFREPDLE KKYSKQVDDR FGAYVACASL VFLFICFVQI 

       790        800        810        820        830        840 
TIVPHSIFML SFYLTCSLLL TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF 

       850        860        870        880        890        900 
TITLVFLAAF VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP 

       910        920        930        940        950        960 
WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP GVTLFDNADL 

       970        980        990       1000       1010       1020 
LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA LYLHAQQVES TARLDFLWKL 

      1030       1040       1050       1060       1070       1080 
QATEEKEEME ELQAYNRRLL HNILPKDVAA HFLARERRND ELYYQSCECV AVMFASIANF 

      1090       1100       1110       1120       1130       1140 
SEFYVELEAN NEGVECLRLL NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY 

      1150       1160       1170       1180       1190       1200 
DKVGKTHIKA LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG 

      1210       1220       1230       1240       1250       1260 
NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM TYFLNGGPPL 


S

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References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
Ludwig M.G., Seuwen K.
J. Recept. Signal Transduct. Res. 22:79-110(2002) [PubMed: 12503609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-1261.
Tissue: Heart.
[3]"Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues."
Raimundo S., Giray J., Volff J.-N., Schwab M., Altenbuchner J., Ratge D., Wisser H.
Clin. Chim. Acta 285:155-161(1999) [PubMed: 10481931] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-664.
Tissue: Heart muscle.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AC025571 Genomic DNA. No translation available.
AF497517 mRNA. Translation: AAM94374.1.
U65473 mRNA. Translation: AAD00121.1.
BK000371 mRNA. Translation: DAA00057.1.
RefSeqNP_899200.1.
UniGeneHs.593293
Hs.655144

3D structure databases

HSSPHSSP built from PDB template 1AZS based on UniProtKB P30803.
SMRO95622. Positions 454-643.
ModBaseSearch...

PTM databases

PhosphoSiteO95622.

Genome annotation databases

EnsemblENSG00000173175. Homo sapiens. [Contig view]
GeneID111.
KEGGhsa:111.

Organism-specific databases

H-InvDBHIX0003612.
HGNCHGNC:236. ADCY5.
HPAHPA017730.
MIM600293. gene.
PharmGKBPA24563.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO95622.
HOVERGENO95622.

Gene expression databases

ArrayExpressO95622.
CleanExHS_ADCY5.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR009398. Aden_cycl_like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio427.
SOURCESearch...

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Entry information

Entry nameADCY5_HUMAN
AccessionPrimary (citable) accession number: O95622
Secondary accession number(s): Q7RTV7, Q8NFM3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 28, 2006
Last modified: November 25, 2008
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents