Amyloid beta A4 precursor protein-binding family B member 3

Names and origin

Protein names

Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 3
Alternative name(s):
    Fe65-like protein 2
      Short name=Fe65L2

Gene names

Name:	APBB3
Synonyms:	FE65L2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May modulate the internalization of beta-amyloid precursor protein.
Subunit structure	Binds to the intracellular domain of the beta-amyloid precursor protein. Also bind to APP-like proteins.
Tissue specificity	Expressed in various tissues.
Sequence similarities	Contains 2 PID domains. Contains 1 WW domain.

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Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	3D-structure
Gene Ontology (GO)
Cellular component	cytoplasm Ref.1 Traceable author statement. Source: ProtInc cytoskeleton Inferred from direct assay. Source: HPA
Molecular function	protein binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform II (identifier: O95704-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform I (identifier: O95704-2) The sequence of this isoform differs from the canonical sequence as follows: 210-211: Missing.

Isoform III (identifier: O95704-3) The sequence of this isoform differs from the canonical sequence as follows: 210-210: D → PISAPA

Isoform IV (identifier: O95704-4) The sequence of this isoform differs from the canonical sequence as follows: 210-210: D → DSPISAPA

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 486

486

Amyloid beta A4 precursor protein-binding family B member 3

PRO_0000076054

Regions

Domain

29 – 61

33

WW

Domain

113 – 280

168

PID 1

Domain

285 – 440

156

PID 2

Natural variations

Alternative sequence

210 – 211

2

Missing in isoform I.

VSP_006799

Alternative sequence

210

1

D → PISAPA in isoform III.

VSP_006800

Alternative sequence

210

1

D → DSPISAPA in isoform IV.

VSP_006801

Natural variant

165

1

G → R: dbSNP rs7715021.

VAR_029518

Natural variant

231

1

R → C: dbSNP rs250430.

VAR_024702

Secondary structure

1

.

486

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform II [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 494DFB422355EFA5 Show »	FASTA	486	52,638
10 20 30 40 50 60 MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT 70 80 90 100 110 120 WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA 130 140 150 160 170 180 VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS 190 200 210 220 230 240 LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVASDK DSCMLKCHVF RCDVPAKAIA 250 260 270 280 290 300 SALHGLCAQI LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP 310 320 330 340 350 360 VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE EEPLWQCPVR 370 380 390 400 410 420 LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS EAVQAACMVQ YQKCLVASAA 430 440 450 460 470 480 RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP « Hide
Isoform I [UniParc]. Checksum: 362761550F0CF984 Show »		484	52,367
10 20 30 40 50 60 MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT 70 80 90 100 110 120 WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA 130 140 150 160 170 180 VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS 190 200 210 220 230 240 LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD FAFVASDKDS CMLKCHVFRC DVPAKAIASA 250 260 270 280 290 300 LHGLCAQILS ERVEVSGDAS CCSPDPISPE DLPRQVELLD AVSQAAQKYE ALYMGTLPVT 310 320 330 340 350 360 KAMGMDVLNE AIGTLTARGD RNAWVPTMLS VSDSLMTAHP IQAEASTEEE PLWQCPVRLV 370 380 390 400 410 420 TFIGVGRDPH TFGLIADLGR QSFQCAAFWC QPHAGGLSEA VQAACMVQYQ KCLVASAARG 430 440 450 460 470 480 KAWGAQARAR LRLKRTSSMD SPGGPLPLPL LKGGVGGAGA TPRKRGVFSF LDAFRLKPSL LHMP « Hide
Isoform III [UniParc]. Checksum: 193A8699641578E6 Show »		491	53,060
10 20 30 40 50 60 MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT 70 80 90 100 110 120 WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA 130 140 150 160 170 180 VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS 190 200 210 220 230 240 LVNPLDHSLI HCQPLVHIRV WGVGSSKGRP ISAPARDFAF VASDKDSCML KCHVFRCDVP 250 260 270 280 290 300 AKAIASALHG LCAQILSERV EVSGDASCCS PDPISPEDLP RQVELLDAVS QAAQKYEALY 310 320 330 340 350 360 MGTLPVTKAM GMDVLNEAIG TLTARGDRNA WVPTMLSVSD SLMTAHPIQA EASTEEEPLW 370 380 390 400 410 420 QCPVRLVTFI GVGRDPHTFG LIADLGRQSF QCAAFWCQPH AGGLSEAVQA ACMVQYQKCL 430 440 450 460 470 480 VASAARGKAW GAQARARLRL KRTSSMDSPG GPLPLPLLKG GVGGAGATPR KRGVFSFLDA 490 FRLKPSLLHM P « Hide
Isoform IV [UniParc]. Checksum: 42B279F50B2EEF92 Show »		493	53,262
10 20 30 40 50 60 MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT 70 80 90 100 110 120 WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA 130 140 150 160 170 180 VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS 190 200 210 220 230 240 LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD SPISAPARDF AFVASDKDSC MLKCHVFRCD 250 260 270 280 290 300 VPAKAIASAL HGLCAQILSE RVEVSGDASC CSPDPISPED LPRQVELLDA VSQAAQKYEA 310 320 330 340 350 360 LYMGTLPVTK AMGMDVLNEA IGTLTARGDR NAWVPTMLSV SDSLMTAHPI QAEASTEEEP 370 380 390 400 410 420 LWQCPVRLVT FIGVGRDPHT FGLIADLGRQ SFQCAAFWCQ PHAGGLSEAV QAACMVQYQK 430 440 450 460 470 480 CLVASAARGK AWGAQARARL RLKRTSSMDS PGGPLPLPLL KGGVGGAGAT PRKRGVFSFL 490 DAFRLKPSLL HMP « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein." Tanahashi H. Neurosci. Lett. 261:143-146(1999) [PubMed: 10081969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I AND II). Tissue: Brain.
[2]	"Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein." Tanahashi H., Tabira T. Biochem. Biophys. Res. Commun. 258:385-389(1999) [PubMed: 10329396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Molecular cloning of the full-length cDNA and novel splicing isoforms of Fe65L2 gene." Mao Y.M., Xie Y., Sun Z., Chen X.M., Ying K., Dai J.L., Lin S., Wu C.Q., Li Y. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I; II; III AND IV).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM II), VARIANT CYS-231.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AB018247 mRNA. Translation: BAA35188.1.
AB024745 Genomic DNA. Translation: BAA78674.1.
AF224708 mRNA. Translation: AAF65172.1.
AF224709 mRNA. Translation: AAF65173.1.
AF224710 mRNA. Translation: AAF65174.1.
AF224711 mRNA. Translation: AAF65175.1.
BC125187 mRNA. Translation: AAI25188.1.

UniGene

Hs.529449

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DYQ	X-ray	3.10	A	281-417	[»]
2YSC	NMR	-	A	30-61	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O95704.

PTM databases

PhosphoSite

O95704.

Genome annotation databases

Ensembl

ENSG00000113108. Homo sapiens. [Contig view]

Organism-specific databases

H-InvDB

HIX0005232.

HGNC

HGNC:20708. APBB3.

HPA

HPA005571.

MIM

602711. gene.

PharmGKB

PA134958636.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOVERGEN

O95704.

Gene expression databases

ArrayExpress

O95704.

CleanEx

HS_APBB3.

GermOnline

ENSG00000113108. Homo sapiens.

Family and domain databases

InterPro

IPR011993. PH_type.
IPR006020. PTB_PID.
IPR001202. WW_Rsp5_WWP.
[Graphical view]

Gene3D

G3DSA:2.30.29.30. PH_type. 1 hit.

Pfam

PF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]

SMART

SM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]

PROSITE

PS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

SOURCE

Search...

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Entry information

Entry name

APBB3_HUMAN

Accession

Primary (citable) accession number: O95704
Secondary accession number(s): Q08AG4

Q9NYX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents