Reviewed, UniProtKB/Swiss-Prot P00029 (CYC_ASTRU)

Names and origin

Protein names	Recommended name:     Cytochrome c
Organism	Asterias rubens (Common European starfish)
Taxonomic identifier	7604 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Echinodermata › Eleutherozoa › Asterozoa › Asteroidea › Forcipulatacea › Forcipulatida › Asteriidae › Asterias

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 104	103	Cytochrome c
Sites
	Metal binding	19	1	Iron (heme axial ligand)
	Metal binding	81	1	Iron (heme axial ligand)
	Binding site	15	1	Heme (covalent)
	Binding site	18	1	Heme (covalent)

Sequences

	Sequence		Length	Mass (Da)
	P00029-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A0984E9258A7F154	FASTA	104	11,661
	10 20 30 40 50 60 MGQVEKGKKI FVQRCAQCHT VEKAGKHKTG PNLNGILGRK TGQAAGFSYT DANRNKGITW 70 80 90 100 KNETLFEYLE NPKKYIPGTK MVFAGLKKQK ERQDLIAYLE AATK

References

[1]	"The amino acid sequence of cytochrome c from Asterias rubens L. (common starfish)." Lyddiatt A., Boulter D. FEBS Lett. 67:331-334(1976) [PubMed: 183984] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-104.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
PIR	CCSF. A00026.
3D structure databases
HSSP	HSSP built from PDB template 2PCB based on UniProtKB P00004.
SMR	P00029. Positions 2-103.
ModBase	Search...
Family and domain databases
InterPro	IPR009056. Cyt_c_monohaem. IPR003088. Cyt_CI. IPR002327. Cyt_CIAB. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
ProDom	PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CYC_ASTRU

Accession

Primary (citable) accession number: P00029

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)