Reviewed, UniProtKB/Swiss-Prot P00700 (LYSC_COLVI)

Names and origin

Protein names

Lysozyme C
Also known as:
     EC 3.2.1.17
     1,4-beta-N-acetylmuramidase C

Gene names

Name:

LYZ

Organism

Colinus virginianus (Bobwhite quail) (Common bobwhite)

Taxonomic identifier

9014 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Odontophoridae › Colinus

Protein existence

Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 129

129

Lysozyme C

Sites

Active site

35

1

Active site

52

1

Amino acid modifications

Disulfide bond

6 ↔ 127

Disulfide bond

30 ↔ 115

Disulfide bond

64 ↔ 80

Disulfide bond

76 ↔ 94

Secondary structure

1

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129

Helix Strand Turn

Details...

Helix

5 – 14

10

Helix

25 – 36

12

Beta strand

43 – 45

3

Beta strand

51 – 53

3

Turn

54 – 57

4

Turn

60 – 62

3

Helix

80 – 84

5

Beta strand

85 – 87

3

Helix

89 – 101

13

Helix

104 – 107

4

Helix

109 – 114

6

Turn

115 – 117

3

Helix

120 – 124

5

Sequences

	Sequence		Length	Mass (Da)
	P00700-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 1C5797001951FF38	FASTA	129	14,271
	10 20 30 40 50 60 KVFGRCELAA AMKRHGLDNY RGYSLGNWVC AAKFESNFNS QATNRNTDGS TDYGVLQINS 70 80 90 100 110 120 RWWCNDGKTP GSRNLCNIPC SALLSSDITA TVNCAKKIVS DGNGMNAWVA WRNRCKGTDV QAWIRGCRL

References

[1]	"Amino acid sequence studies on bobwhite quail egg white lysozyme." Prager E.M., Arnheim N., Mross G.A., Wilson A.C. J. Biol. Chem. 247:2905-2916(1972) [PubMed: 4112539] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Egg white.
[2]	"Refined structures of bobwhite quail lysozyme uncomplexed and complexed with the HyHEL-5 Fab fragment." Chacko S., Silverton E.W., Smith-Gill S.J., Davies D.R., Schick K.A., Xavier K.A., Willson R.C., Jeffrey P.D., Chang C.Y., Sieker L.C., Sheriff S. Proteins 26:55-65(1996) [PubMed: 8880929] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Cross-references

Sequence databases

PIR

LZQJEB. A00855.

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BQL	X-ray	2.60	Y	1-129	[»]
1DKJ	X-ray	2.00	A	1-129	[»]
1DKK	X-ray	1.90	A/B	1-129	[»]

ModBase

Search...

Phylogenomic databases

HOVERGEN

P00700.

Family and domain databases

InterPro

IPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
[Graphical view]

Pfam

PF00062. Lys. 1 hit.
[Graphical view]

PRINTS

PR00137. LYSOZYME.
PR00135. LYZLACT.

SMART

SM00263. LYZ1. 1 hit.
[Graphical view]

PROSITE

PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

ProDom

P00700.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

LinkHub

P00700.

ProtoNet

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Entry information

Entry name

LYSC_COLVI

Accession

Primary (citable) accession number: P00700

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	November 1, 1997
Last modified:	June 10, 2008
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)