Reviewed, UniProtKB/Swiss-Prot P00708 (LYSC_COLLI)

Names and origin

Protein names

Recommended name:
    Lysozyme C
    EC=3.2.1.17
Alternative name(s):
    1,4-beta-N-acetylmuramidase C

Gene names

Name:

LYZ

Organism

Columba livia (Domestic pigeon)

Taxonomic identifier

8932 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Columbiformes › Columbidae › Columba

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Cofactor	Binds 1 calcium ion per subunit.
Subunit structure	Monomer.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Ligand	Calcium
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW lysozyme activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Lysozyme C		PRO_0000208862
Regions
	Calcium binding	81 – 92	12	By similarity
Sites
	Active site	35	1	By similarity
	Active site	52	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 127		By similarity
	Disulfide bond	30 ↔ 115		By similarity
	Disulfide bond	64 ↔ 80		By similarity
	Disulfide bond	76 ↔ 94		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00708-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 96D3BAFDFD934DD8	FASTA	127	14,452
	10 20 30 40 50 60 KDIPRCELVK ILRRHGFEGF VGKTVANWVC LVKHESGYRT TAFNNNGPNS RDYGIFQINS 70 80 90 100 110 120 KYWCNDGKTR GSKNACNINC SKLRDDNIAD DIQCAKKIAR EARGLTPWVA WKKYCQGKDL SSYVRGC

References

[1]	"Amino acid sequence of pigeon egg-white lysozyme." Rodriguez R., Menendez-Arias L., Gonzalez de Buitrago G., Gavilanes J.G. Biochem. Int. 11:841-843(1985) [PubMed: 4091856] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Egg white.
[2]	"Calcium-binding lysozymes." Nitta K., Tsuge H., Shimazaki K., Sugai S. Biol. Chem. Hoppe-Seyler 369:671-675(1988) [PubMed: 3214551] [Abstract] Cited for: CALCIUM-BINDING DATA.
[3]	"Crystallization and preliminary X-ray structure analysis of pigeon egg-white lysozyme." Yao M., Tanaka I., Hikichi K., Nitta K. J. Biochem. 111:1-3(1992) [PubMed: 1607355] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Cross-references

Sequence databases
PIR	LZPY. A00863.
3D structure databases
HSSP	HSSP built from PDB template 1JUG based on UniProtKB P37156.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P00708.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSC_COLLI

Accession

Primary (citable) accession number: P00708

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)