Reviewed, UniProtKB/Swiss-Prot P01607 (KV115_HUMAN)

Names and origin

Protein names	Recommended name:     Ig kappa chain V-I region Rei
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (1,2) marker. This is a Bence-Jones protein.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
Molecular function	Bence-Jones protein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	antigen binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – ›108

›108

Ig kappa chain V-I region Rei

PRO_0000059749

Regions

Region

1 – 23

23

Framework-1

Region

24 – 34

11

Complementarity-determining-1

Region

35 – 49

15

Framework-2

Region

50 – 56

7

Complementarity-determining-2

Region

57 – 88

32

Framework-3

Region

89 – 97

9

Complementarity-determining-3

Region

98 – 107

10

Framework-4

Amino acid modifications

Disulfide bond

23 ↔ 88

Experimental info

Non-terminal residue

108

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

108

Helix Strand Turn

Details...

Beta strand

4 – 7

4

Beta strand

9 – 13

5

Beta strand

19 – 27

9

Beta strand

33 – 38

6

Beta strand

45 – 49

5

Turn

50 – 52

3

Beta strand

62 – 67

6

Beta strand

70 – 77

8

Helix

80 – 82

3

Beta strand

84 – 90

7

Beta strand

92 – 95

4

Beta strand

102 – 106

5

Sequences

	Sequence		Length	Mass (Da)
	P01607-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 9E8143E1188BCE2A	FASTA	108	11,902
	10 20 30 40 50 60 DIQMTQSPSS LSASVGDRVT ITCQASQDII KYLNWYQQTP GKAPKLLIYE ASNLQAGVPS 70 80 90 100 RFSGSGSGTD YTFTISSLQP EDIATYYCQQ YQSLPYTFGQ GTKLQITR

References

[1]	"The primary structure of a crystalline monoclonal immunoglobulin kappa-type L-chain, subgroup I (Bence-Jones protein Rei); isolation and characterization of the tryptic peptides; the complete amino acid sequence of the protein; a contribution to the elucidation of the three-dimensional structure of antibodies, in particular their combining site." Palm W., Hilschmann N. Hoppe-Seyler's Z. Physiol. Chem. 356:167-191(1975) [PubMed: 809329] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution." Epp O., Lattman E.E., Schiffer M., Huber R., Palm W. Biochemistry 14:4943-4952(1975) [PubMed: 1182131] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

PIR

K1HURE. A91663.

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AR2	X-ray	2.80	A	1-107	[»]
1BWW	X-ray	1.70	A/B	1-107	[»]
1REI	X-ray	2.00	A/B	1-107	[»]

ModBase

Search...

Organism-specific databases

GeneCards

Search...

Phylogenomic databases

HOVERGEN

P01607.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

LinkHub

P01607.

Entry information

Entry name

KV115_HUMAN

Accession

Primary (citable) accession number: P01607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	July 22, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)