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Reviewed, UniProtKB/Swiss-Prot P01869 (IGH1M_MOUSE)

Last modified November 25, 2008. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ig gamma-1 chain C region, membrane-bound form
Gene names
Name: Ighg1
Synonyms: Igh-4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane proteinPotential.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Membrane-bound (identifier: P01869-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Secreted (identifier: P01868-1)

The sequence of this isoform can be found in the external entry P01868-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Notes: May be the major isoform.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 393›393Ig gamma-1 chain C region, membrane-bound form
PRO_0000153583

Regions

Transmembrane340 – 35718 Potential
Topological domain358 – 39336Cytoplasmic Potential
Region1 – 9797CH1
Region98 – 11013Hinge
Region111 – 217107CH2
Region218 – 324107CH3

Amino acid modifications

Glycosylation1741N-linked (GlcNAc...)
Disulfide bond27 ↔ 82
Disulfide bond102Interchain (with a light chain)
Disulfide bond104Interchain (with a heavy chain)
Disulfide bond107Interchain (with a heavy chain)
Disulfide bond109Interchain (with a heavy chain)
Disulfide bond138 ↔ 198
Disulfide bond244 ↔ 302

Experimental info

Non-terminal residue11

Secondary structure

1 ................................................. 393
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform Membrane-bound [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: 4CC88343B7A1CE27

FASTA39343,387
        10         20         30         40         50         60 
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD 

        70         80         90        100        110        120 
LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF 

       130        140        150        160        170        180 
PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV 

       190        200        210        220        230        240 
SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV 

       250        260        270        280        290        300 
SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF 

       310        320        330        340        350        360 
TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA 

       370        380        390 
AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP

« Hide

Isoform Secreted.

See P01868.

––

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References

[1]"Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene."
Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., Takahashi N., Mano Y.
Cell 18:559-568(1979) [PubMed: 115593] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain."
Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O.
Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982) [PubMed: 6804950] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-393.
[3]"Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains."
Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., Eisenberg D., Wall R.
Cell 26:19-27(1981) [PubMed: 6799207] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-366.
[4]"Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains."
Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.
Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982) [PubMed: 6283537] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
+Additional computationally mapped references.

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Cross-references

Sequence databases

J00453 Genomic DNA. No translation available.
PIRG1MSM. B02159.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50H1-98[»]
1ACYX-ray3.00H1-100[»]
1AE6X-ray3.00H1-98[»]
1CICX-ray2.50D1-102[»]
1CL7X-ray3.00I21-102[»]
1F11X-ray3.00B/D1-102[»]
1F58X-ray2.00H1-102[»]
1IGYX-ray3.20B/D1-320[»]
1KC5X-ray2.50H1-101[»]
1KCRX-ray2.90H1-102[»]
1KENX-ray3.50H/T1-101[»]
1ORSX-ray1.90B1-103[»]
1S5IX-ray2.70H1-102[»]
25C8X-ray2.00H1-98[»]
2AJSX-ray1.70H1-100[»]
2AJUX-ray1.50H1-100[»]
2AJVX-ray1.50H1-100[»]
2AJXX-ray1.85H1-100[»]
2AJYX-ray2.10H1-100[»]
2AJZX-ray2.30B/H1-100[»]
2AK1X-ray1.85H1-100[»]
ModBaseSearch...

Protein family/group databases

IMGTSearch...

Genome annotation databases

EnsemblENSMUSG00000076614. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:96446. Ighg1.

Phylogenomic databases

HOVERGENP01869.

Gene expression databases

ArrayExpressP01869.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07654. C1-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubP01869.
SOURCESearch...

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Entry information

Entry nameIGH1M_MOUSE
AccessionPrimary (citable) accession number: P01869
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1991
Last modified: November 25, 2008
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents