Serum albumin precursor - Bos taurus (Bovine)

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Reviewed, UniProtKB/Swiss-Prot P02769 (ALBU_BOVIN)

Last modified April 8, 2008. Version 84. History...

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Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Serum albumin [Precursor]
Also known as:
Allergen Bos d 6
BSA

Gene names

Name:

ALB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein existence

Evidence at protein level.

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General annotation (Comments)

Function	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Subcellular location	Secreted.
Tissue specificity	Plasma.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains.
Caution	A peptide arising from positions 165 to 173 was originally (Ref.14) termed neurotensin-related peptide (NRP) and was thought to regulates fat digestion, lipid absorption, and blood flow.

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Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Allergen
Domain	Repeat Signal
Ligand	Copper Lipid-binding Metal-binding
PTM	Cleavage on pair of basic residues
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	Cellular response to starvation Inferred from sequence or structural similarity. Source: UniProtKB Hemolysis by symbiont of host red blood cells Inferred from sequence or structural similarity. Source: UniProtKB Maintenance of mitochondrion localization Inferred from sequence or structural similarity. Source: UniProtKB Negative regulation of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	Protein complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB Drug binding Inferred from sequence or structural similarity. Source: UniProtKB Fatty acid binding Inferred from sequence or structural similarity. Source: UniProtKB Protein binding Inferred from sequence or structural similarity. Source: UniProtKB Pyridoxal phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB Toxin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

1 – 18

Propeptide

19 – 24

Chain

25 – 607

583

Serum albumin

Regions

Domain

25 – 204

180

Albumin 1

Domain

211 – 396

186

Albumin 2

Domain

403 – 594

192

Albumin 3

Sites

Metal binding

Copper By similarity

Amino acid modifications

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Natural variations

Natural variant

214

A → T

Experimental info

Sequence conflict

Missing AA sequence Ref.11

Sequence conflict

116

E → A in AAI02743. Ref.5

Sequence conflict

173

Y → L AA sequence Ref.14

Sequence conflict

302

C → K AA sequence Ref.9

Sequence conflict

304 – 305

KP → PC AA sequence Ref.9

Sequence conflict

324

N → D AA sequence Ref.9

Sequence conflict

394 – 395

ST → TS AA sequence Ref.9

Sequence conflict

429

A → E in AAI02743. Ref.5

Sequence conflict

437

K → R AA sequence Ref.16

Sequence conflict

472

T → A in AAI02743. Ref.5

Sequence conflict

493 – 494

SE → ES AA sequence Ref.9

Sequence conflict

579

D → G in AAI02743. Ref.5

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Sequences

Sequence

Length

Mass (Da)

Tools

P02769-1 [UniParc].

Last modified February 1, 1996. Version 4.
Checksum: 39167DFE768585D4
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FASTA

607

69,293

        10         20         30         40         50         60 
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFKDLGE EHFKGLVLIA FSQYLQQCPF 

        70         80         90        100        110        120 
DEHVKLVNEL TEFAKTCVAD ESHAGCEKSL HTLFGDELCK VASLRETYGD MADCCEKQEP 

       130        140        150        160        170        180 
ERNECFLSHK DDSPDLPKLK PDPNTLCDEF KADEKKFWGK YLYEIARRHP YFYAPELLYY 

       190        200        210        220        230        240 
ANKYNGVFQE CCQAEDKGAC LLPKIETMRE KVLASSARQR LRCASIQKFG ERALKAWSVA 

       250        260        270        280        290        300 
RLSQKFPKAE FVEVTKLVTD LTKVHKECCH GDLLECADDR ADLAKYICDN QDTISSKLKE 

       310        320        330        340        350        360 
CCDKPLLEKS HCIAEVEKDA IPENLPPLTA DFAEDKDVCK NYQEAKDAFL GSFLYEYSRR 

       370        380        390        400        410        420 
HPEYAVSVLL RLAKEYEATL EECCAKDDPH ACYSTVFDKL KHLVDEPQNL IKQNCDQFEK 

       430        440        450        460        470        480 
LGEYGFQNAL IVRYTRKVPQ VSTPTLVEVS RSLGKVGTRC CTKPESERMP CTEDYLSLIL 

       490        500        510        520        530        540 
NRLCVLHEKT PVSEKVTKCC TESLVNRRPC FSALTPDETY VPKAFDEKLF TFHADICTLP 

       550        560        570        580        590        600 
DTEKQIKKQT ALVELLKHKP KATEEQLKTV MENFVAFVDK CCAADDKEAC FAVEGPKLVV 


STQTALA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bovine serum albumin: cDNA sequence and expression." Holowachuk E.W., Stoltenborg J.K., Reed R.G., Peters T. Jr. Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The bovine serum albumin mRNA." Barry T., Power S., Gannon F. Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-214. Tissue: Liver.
[3]	"Differential binding of IgG and IgA antibodies to antigenic determinants of bovine serum albumin." Hilger C., Grigioni F., De Beaufort C., Michel G., Freilinger J., Hentges F. Clin. Exp. Immunol. 123:387-394(2001) [PubMed: 11298124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"The complete cDNA sequence of bovine serum albumin." Wu H.T., Huang M.C. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-214.
[5]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-214. Strain: Hereford. Tissue: Fetal liver and Testis.
[6]	"Biosynthesis of bovine plasma proteins in a cell-free system. Amino-terminal sequence of preproalbumin." McGillivray R.T.A., Chung D.W., Davie E.W. Eur. J. Biochem. 98:477-485(1979) [PubMed: 488109] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-32.
[7]	"Bovine microsomal albumin: amino terminal sequence of bovine proalbumin." Patterson J.E., Geller D.M. Biochem. Biophys. Res. Commun. 74:1220-1226(1977) [PubMed: 843354] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-28.
[8]	"Rapid confirmation and revision of the primary structure of bovine serum albumin by ESIMS and Frit-FAB LC/MS." Hirayama K., Akashi S., Furuya M., Fukuhara K. Biochem. Biophys. Res. Commun. 173:639-646(1990) [PubMed: 2260975] [Abstract] Cited for: PROTEIN SEQUENCE, SEQUENCE REVISION TO 118-119 AND 180.
[9]	"Structure of bovine serum albumin." Brown J.R. Fed. Proc. 34:591-591(1975) Cited for: PROTEIN SEQUENCE OF 25-424 AND 429-607, VARIANT THR-214.
[10]	Brown J.R. Submitted (APR-1975) to the PIR data bank Cited for: SEQUENCE REVISION TO 190-195.
[11]	"Tooth 'enamelins' identified mainly as serum proteins. Major 'enamelin' is albumin." Strawich E., Glimcher M.J. Eur. J. Biochem. 191:47-56(1990) [PubMed: 2379503] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-64.
[12]	"Electroblotting onto glass-fiber filter from an analytical isoelectrofocusing gel: a preparative method for isolating proteins for N-terminal microsequencing." Hsieh J.C., Lin F.P., Tam M.F. Anal. Biochem. 170:1-8(1988) [PubMed: 3389500] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-41.
[13]	"Structures of histamine-releasing peptides formed by the action of acid proteases on mammalian albumin(s)." Carraway R.E., Cochrane D.E., Boucher W., Mitra S.P. J. Immunol. 143:1680-1684(1989) [PubMed: 2474609] [Abstract] Cited for: PROTEIN SEQUENCE OF 163-172.
[14]	"Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)." Carraway R.E., Mitra S.P., Cochrane D.E. J. Biol. Chem. 262:5968-5973(1987) [PubMed: 2437111] [Abstract] Cited for: PROTEIN SEQUENCE OF 165-173. Tissue: Plasma.
[15]	"Sequence of residues 400-403 of bovine serum albumin." Reed R.G., Putnam F.W., Peters T. Jr. Biochem. J. 191:867-868(1980) [PubMed: 7283978] [Abstract] Cited for: PROTEIN SEQUENCE OF 402-433.
[16]	Vilbois F. Submitted (AUG-1998) to UniProtKB Cited for: PROTEIN SEQUENCE OF 437-451.
[17]	"Structure of serum albumin: disulfide bridges." Brown J.R. Fed. Proc. 33:1389-1389(1974) Cited for: DISULFIDE BONDS.

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Cross-references

Sequence databases
	M73993 mRNA. Translation: AAA51411.1. X58989 mRNA. Translation: CAA41735.1. Y17769 mRNA. Translation: CAA76847.1. AF542068 mRNA. Translation: AAN17824.1. BC102742 mRNA. Translation: AAI02743.1. BC142272 mRNA. Translation: AAI42273.1.
PIR	ABBOS. A38885.
RefSeq	NP_851335.1.
UniGene	Bt.48997
3D structure databases
HSSP	HSSP built from PDB template 1HK1 based on UniProtKB P02768.
SMR	P02769. Positions 27-607.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000017121. Bos taurus. [Contig view]
GeneID	280717.
Family and domain databases
InterPro	IPR001703. Alphafetoprot. IPR000264. Serum_albumin. IPR014760. Serum_albumin_N. [Graphical view]
Pfam	PF00273. Serum_albumin. 3 hits. [Graphical view]
PRINTS	PR00803. AFETOPROTEIN. PR00802. SERUMALBUMIN.
ProDom	PD002486. Serum_albumin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00103. ALBUMIN. 3 hits. [Graphical view]
PROSITE	PS00212. ALBUMIN. 3 hits. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

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Entry information

Entry name

ALBU_BOVIN

Accession

Primary (citable) accession number: P02769
Secondary accession number(s): A5PJX3

Q3SZR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1996
Last modified:	April 8, 2008
This is version 84 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Allergens

Nomenclature of allergens and list of entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

Other Resources

Entry information

Relevant documents