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Reviewed, UniProtKB/Swiss-Prot P02831 (HXA3_MOUSE)

Last modified September 2, 2008. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A3
Alternative name(s):
    Hox-1.5
    MO-10
Gene names
Name: Hoxa3
Synonyms: Hox-1.5, Hoxa-3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

Subcellular location

Nucleus.

Developmental stage

Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 443443Homeobox protein Hox-A3

Regions

DNA binding192 – 25160Homeobox
Motif156 – 1616Antp-type hexapeptide
Compositional bias79 – 13860Pro-rich

Experimental info

Sequence conflict1851S → G Ref.4 Ref.5
Sequence conflict1951A → G Ref.4 Ref.5
Sequence conflict201 – 2022SA → RP Ref.4 Ref.5
Sequence conflict2181C → M Ref.4 Ref.5

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Sequences

Sequence LengthMass (Da)Tools
P02831-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 6C0E184B0F6F2D40

FASTA44346,430
        10         20         30         40         50         60 
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA CSLQSPASAG 

        70         80         90        100        110        120 
GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP 

       130        140        150        160        170        180 
PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC 

       190        200        210        220        230        240 
AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF 

       250        260        270        280        290        300 
QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 

       310        320        330        340        350        360 
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL QGNGSYGTPH 

       370        380        390        400        410        420 
LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG TGPLGSGHHH GPGPGEPHPT 

       430        440 
YTDLTAHHPS QGRIQEAPKL THL

« Hide

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References

« Hide 'large scale' references
[1]Hofmann M., Boehm T.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"Sequence and expression of the murine Hoxd-3 homeobox gene."
Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed: 8710855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
Strain: ICR X Swiss Webster.
[4]"Structural and functional aspects of the mammalian homeo-box sequences."
Ruddle F.H., Hart C.P., McGinnis W.
Trends Genet. 1:48-51(1985)
Cited for: NUCLEOTIDE SEQUENCE OF 185-258.
[5]"Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila."
McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.
Cell 38:675-680(1984) [PubMed: 6091896] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
[6]"The homeo domain of a murine protein binds 5' to its own homeo box."
Fainsod A., Bogarad L.D., Ruusala T., Lubin M., Crothers D.M., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 83:9532-9536(1986) [PubMed: 2879282] [Abstract]
Cited for: DNA-BINDING.
[7]"Expression of the murine homeo box gene Hox 1.5 during embryogenesis."
Fainsod A., Awgulewitsch A., Ruddle F.H.
Dev. Biol. 124:125-133(1987) [PubMed: 2444477] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Y11717 mRNA. Translation: CAA72404.1.
BC096612 mRNA. Translation: AAH96612.1.
U56399 mRNA. Translation: AAC52778.1.
K02591 Genomic DNA. Translation: AAA37822.1.
PIRI49746.
RefSeqNP_034582.1.
UniGeneMm.159945

3D structure databases

HSSPHSSP built from PDB template 1KZ2 based on UniProtKB P09089.
SMRP02831. Positions 194-251.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000079560. Mus musculus. [Contig view]
GeneID15400.
KEGGmmu:15400.

Organism-specific databases

MGIMGI:96175. Hoxa3.

Phylogenomic databases

HOGENOMP02831.
HOVERGENP02831.

Gene expression databases

ArrayExpressP02831.
CleanExMM_HOXA3.
GermOnlineENSMUSG00000059723. Mus musculus.

Family and domain databases

InterProIPR001827. Antennapedia.
IPR001356. Homeobox.
IPR012287. Homeodomain-rel.
IPR000047. HTH_lambrepressr.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameHXA3_MOUSE
AccessionPrimary (citable) accession number: P02831
Secondary accession number(s): Q4V9Z8, Q61197
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: September 2, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents