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Reviewed, UniProtKB/Swiss-Prot P05085 (ARGR2_YEAST)

Last modified July 22, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arginine metabolism regulation protein II
Gene names
Name: ARGR2
Synonyms: ARG81
Ordered Locus Names: YML099C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This protein repress or induces several genes or arginine metabolism.

Subcellular location

Cytoplasm. Nucleus.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

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Ontologies

Keywords

   Biological processArginine metabolism
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processarginine metabolic process

Traceable author statement. Source: SGD

negative regulation of calcium ion-dependent exocytosis

Inferred from direct assay. Source: SGD

   Cellular componentnucleus

Inferred from direct assay. Source: SGD

   Molecular functiontranscription cofactor activity

Inferred from direct assay. Source: SGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 880880Arginine metabolism regulation protein II

Regions

DNA binding21 – 4828Zn(2)-C6 fungal-type

Amino acid modifications

Modified residue1771Phosphoserine

Experimental info

Sequence conflict41S → F in CAA27577. Ref.1
Sequence conflict1291Missing in CAA27577. Ref.1
Sequence conflict2831F → V in CAA27577. Ref.1
Sequence conflict3451D → V in CAA27577. Ref.1
Sequence conflict3661E → Q in CAA27577. Ref.1
Sequence conflict5491T → A in CAA27577. Ref.1
Sequence conflict5971T → S in CAA27577. Ref.1
Sequence conflict6651K → N in CAA27577. Ref.1
Sequence conflict8691V → I in CAA27577. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P05085-1 [UniParc].

Last modified February 1, 1996. Version 3.
Checksum: DA033AB2B373F415

FASTA880100,282
        10         20         30         40         50         60 
MGISSKNGPK KMGRAKTFTG CWTCRGRKVK CDLRHPHCQR CEKSNLPCGG YDIKLRWSKP 

        70         80         90        100        110        120 
MQFDPYGVPI PQNSPATTTN LSGSVDEPQY QRRNIDFVRY DEEYVYHEDM DDELTMLHTP 

       130        140        150        160        170        180 
PIEKISDNKT WIIKKFGVFK GTDKIDKQYA PRKKRNRKRV AKSLESSASI SLSSLPSSST 

       190        200        210        220        230        240 
ISFPIRHIED KLRNKGHVKT GILSANDGVP PTPNLLDYDW NNLNITGYEW ISSELRDDAL 

       250        260        270        280        290        300 
LSAVTLQGHH LGHTQPQEIS LEENSNVVSG EEHVNAKEHG CAFEADNQGS STLPNKAASA 

       310        320        330        340        350        360 
NDKLYQQNLK LLFQKNSSNS EEPDPQALID DVFVNIEPRS LPASDLNKIT LAPPNEESRM 

       370        380        390        400        410        420 
PKSMLELTSY SSDLPPELVD IIPKTDLTVH GLARFLLNHY FNNVADKMTV VVLEKNPWKT 

       430        440        450        460        470        480 
LYFPRALMAL GDLAGLGQSS NSRNALLNAL LAVSCFHLQS KYPRNYKLQK YFLGLGIELR 

       490        500        510        520        530        540 
NQASNFLRLC LNTKSSIPEK YKDVLTAILS MNSIDVVWGT MADCQDHLAL CEDFVESRMK 

       550        560        570        580        590        600 
LRPNISEKTK TLHRIFSFLK LIQDSTALDK VRAKEIVILP SEEDDNYKPL DTSNATTSSS 

       610        620        630        640        650        660 
EPRVDVVQEG LFREALNEND GKIHIEFVKE PITNVSADST PSSTTPPIFT NIATESYYNK 

       670        680        690        700        710        720 
SDISKLVSKT DENIIGTDSL YGLPNSLILL FSDCVRIVRH NEYYNLTYLP VPRKFNELSL 

       730        740        750        760        770        780 
NFEKRLLKWK SEWNFHQENS EGKSFINSTA EALYHHTMSF YFSLIIYYFT MARSLNCQFL 

       790        800        810        820        830        840 
QNYVAKVLDH LNAMEELVDQ KKVKIVPLIW QGFMAGCACT DENRQQEFRR WAAKLAESGV 

       850        860        870        880 
GSYWGARQVM LEVWRRRKED EPGDNWYSVY KDWEMNLMLS

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of the ARGRII regulatory gene and amino acid sequence homologies between ARGRII PPRI and GAL4 regulatory proteins."
Messenguy F., Dubois E., Descamps F.
Eur. J. Biochem. 157:77-81(1986) [PubMed: 3709534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed: 9169872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 0:0-0(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, MASS SPECTROMETRY.

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Cross-references

Sequence databases

X03940 Genomic DNA. Translation: CAA27577.1.
Z46660 Genomic DNA. Translation: CAA86638.1.
PIRS49627.
RefSeqNP_013610.1.

3D structure databases

HSSPHSSP built from PDB template 1PYC based on UniProtKB P12351.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1346N.
IntActP05085.

Genome annotation databases

EnsemblYML099C. Saccharomyces cerevisiae. [Contig view]
GeneID854874.
GenomeReviewsGene locus YML099C in contig Z71257_GR.
KEGGsce:YML099C.
NMPDRfig|4932.3.peg.4647.

Organism-specific databases

CYGDYML099c.
SGDS000004565. ARG81.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP05085.

Gene expression databases

ArrayExpressP05085.
GermOnlineYML099C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001138. Fungi_Trscrp_N.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProDomP05085.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubP05085.
ProtoNetSearch...

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Entry information

Entry nameARGR2_YEAST
AccessionPrimary (citable) accession number: P05085
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: July 22, 2008
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents