Integrin beta-2 precursor - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Integrin beta-2
Alternative name(s):
    Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    Complement receptor C3 subunit beta
    CD_antigen=CD18

Gene names

Name:	ITGB2
Synonyms:	CD18, MFI7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	769 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Subunit structure	Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
Involvement in disease	Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Sequence similarities	Belongs to the integrin beta chain family. Contains 1 VWFA domain.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Disease	Disease mutation
Domain	Repeat Signal Transmembrane
Molecular function	Integrin Receptor
PTM	Glycoprotein Phosphoprotein Pyrrolidone carboxylic acid
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Non-traceable author statement. Source: UniProtKB cell-cell signaling Non-traceable author statement. Source: UniProtKB inflammatory response Non-traceable author statement. Source: UniProtKB integrin-mediated signaling pathway Non-traceable author statement. Source: UniProtKB leukocyte adhesion Inferred from direct assay. Source: UniProtKB neutrophil chemotaxis Inferred from direct assay. Source: UniProtKB regulation of cell shape Non-traceable author statement. Source: UniProtKB regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: UniProtKB
Cellular component	integrin complex Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	protein kinase binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...