Reviewed, UniProtKB/Swiss-Prot P06127 (CD5_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell surface glycoprotein CD5
Alternative name(s):
    Lymphocyte antigen T1/Leu-1
    CD_antigen=CD5

Gene names

Name:	CD5
Synonyms:	LEU1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 3 SRCR domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell proliferation Ref.1 Non-traceable author statement. Source: UniProtKB cell recognition Ref.4 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.4 Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: UniProtKB transmembrane receptor activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

1 – 24

24

Chain

25 – 495

471

T-cell surface glycoprotein CD5

Regions

Topological domain

25 – 372

348

Extracellular Potential

Transmembrane

373 – 402

30

Potential

Topological domain

403 – 495

93

Cytoplasmic Potential

Domain

35 – 133

99

SRCR 1

Domain

159 – 268

110

SRCR 2

Domain

276 – 368

93

SRCR 3

Amino acid modifications

Modified residue

439

1

Phosphoserine

Modified residue

453

1

Phosphotyrosine

Modified residue

460

1

Phosphoserine

Glycosylation

116

1

N-linked (GlcNAc...) Potential

Glycosylation

241

1

N-linked (GlcNAc...) Potential

Disulfide bond

60 ↔ 125

By similarity

Disulfide bond

81 ↔ 132

By similarity

Disulfide bond

107 ↔ 117

By similarity

Disulfide bond

201 ↔ 267

By similarity

Disulfide bond

244 ↔ 250

By similarity

Disulfide bond

301 ↔ 360

By similarity

Disulfide bond

316 ↔ 367

By similarity

Disulfide bond

342 ↔ 350

By similarity

Natural variations

Natural variant

224

1

P → L: dbSNP rs2241002.

Natural variant

461

1

R → H: dbSNP rs637186.

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

495

Helix Strand Turn

Details...

Beta strand

275 – 280

6

Beta strand

286 – 295

10

Beta strand

298 – 301

4

Helix

310 – 318

9

Beta strand

323 – 331

9

Beta strand

339 – 341

3

Beta strand

344 – 346

3

Helix

347 – 349

3

Beta strand

354 – 356

3

Beta strand

362 – 367

6

Sequences

	Sequence		Length	Mass (Da)
	P06127-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 8740DD7623DEE1D3	FASTA	495	54,625
	10 20 30 40 50 60 MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC 70 80 90 100 110 120 SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS 130 140 150 160 170 180 RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS 190 200 210 220 230 240 LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ 250 260 270 280 290 300 NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL 310 320 330 340 350 360 CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC 370 380 390 400 410 420 KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP 430 440 450 460 470 480 TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS RLSAYPALEG VLHRSSMQPD 490 NSSDSDYDLH GAQRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1." Jones N.H., Clabby M.L., Dialynas D.P., Huag H.-J.S., Herzenberg L.A., Strominger J.L. Nature 323:346-349(1986) [PubMed: 3093892] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Evolutionarily conserved transcription regulatory elements within the 5'-flanking region of the human CD5 gene." Calvo J., Sole J., Simarro M., Vives J., Lozano F. Tissue Antigens 47:257-261(1996) [PubMed: 8740779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lymphocyte.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"The B-cell surface protein CD72/Lyb-2 is the ligand for CD5." van de Velde H., von Hoegen I., Luo W., Parnes J.R., Thielemans K. Nature 351:662-665(1991) [PubMed: 1711157] [Abstract] Cited for: INTERACTION WITH CD72/LYB-2.
[5]	"Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry." Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T., Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C. Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed: 12522270] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; TYR-453 AND SER-460, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X04391 mRNA. Translation: CAA27979.1.
X89405 , AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA. Translation: CAA61584.2.
BC027901 mRNA. Translation: AAH27901.1.

PIR

A26396.

RefSeq

NP_055022.2.

UniGene

Hs.58685

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JA4	X-ray	2.21	A	270-369	[»]
2JOP	NMR	-	A	25-134	[»]
2JP0	NMR	-	A	25-134	[»]
2OTT	X-ray	2.50	X/Y	272-369	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:21N.

PTM databases

GlycoSuiteDB

P06127.

PhosphoSite

P06127.

Genome annotation databases

Ensembl

ENSG00000110448. Homo sapiens. [Contig view]

GeneID

921.

Organism-specific databases

H-InvDB

HIX0009680.

HGNC

HGNC:1685. CD5.

HPA

CAB015392.

MIM

153340. gene.

PharmGKB

PA26224.

GenAtlas

Search...

GeneCards

Search...

GeneLynx

Search...

Phylogenomic databases

HOGENOM

P06127.

HOVERGEN

P06127.

Gene expression databases

ArrayExpress

P06127.

CleanEx

HS_CD5.

GermOnline

ENSG00000110448. Homo sapiens.

Family and domain databases

InterPro

IPR001190. Srcr_rcpt.
IPR017448. Srcr_rcpt-rel.
IPR003566. Tcell_CD5.
[Graphical view]

PANTHER

PTHR19331:SF6. Tcell_CD5. 1 hit.

Pfam

PF00530. SRCR. 3 hits.
[Graphical view]

PRINTS

PR00258. SPERACTRCPTR.
PR01409. TCELLCD5.

PROSITE

PS00420. SRCR_1. False negative.
PS50287. SRCR_2. 3 hits.
[Graphical view]

ProDom

P06127.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

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Other Resources

SOURCE

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ProtoNet

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Entry information

Entry name

CD5_HUMAN

Accession

Primary (citable) accession number: P06127

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	July 22, 2008
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)