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P06179

- FLIC_SALTY

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Protein
Flagellin
Gene
fliC, flaF, hag, STM1959

Gene:

fliC, flaF, hag, STM1959
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - - Experimental evidence at protein leveli

UniProt

P06179 - FLIC_SALTY

Protein:

Flagellin
Protein Existence: Experimental evidence at protein level

Functioni

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.

GO - Molecular functioni

  1. structural molecule activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. structural molecule activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1970-MONOMER.
ReactomeiREACT_147795. Innate Immune System.
REACT_6900. Immune System.
REACT_75813. Ipaf is activated.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellin
Alternative name(s):
Phase 1-I flagellin
Gene namesi
Name:fliC
Synonyms:flaF, hag
Ordered Locus Names:STM1959
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. bacterial-type flagellum filamentInferred from electronic annotationi Source: InterPro
  2. extracellular regionInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Initiator methioninei11Removed By similarity
Chaini2 – 495494Flagellin
PRO_0000182578

Proteomic databases

PaxDbiP06179.
PRIDEiP06179.

Expressioni

Inductioni

Inhibited in nutrient-poor medium (at protein level).1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliSP266096EBI-2011501,EBI-2011519

Protein-protein interaction databases

DIPiDIP-43768N.
IntActiP06179. 1 interaction.
MINTiMINT-2831235.
STRINGi99287.STM1959.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Helixi59 – 9941
Helixi106 – 12924
Turni137 – 1393
Beta strandi142 – 1476
Beta strandi149 – 1513
Beta strandi155 – 1606
Turni165 – 1695
Beta strandi180 – 1856
Beta strandi190 – 1978
Helixi200 – 2023
Turni204 – 2063
Helixi208 – 2103
Beta strandi212 – 2176
Beta strandi219 – 2235
Turni225 – 2273
Beta strandi230 – 2378
Beta strandi244 – 2507
Turni252 – 2543
Beta strandi256 – 2605
Beta strandi277 – 2859
Helixi286 – 2883
Helixi290 – 2989
Beta strandi305 – 3139
Beta strandi319 – 32810
Beta strandi331 – 3377
Beta strandi343 – 3453
Beta strandi353 – 3564
Beta strandi361 – 3666
Beta strandi371 – 3766
Beta strandi379 – 3824
Helixi383 – 3864
Turni391 – 3933
Helixi408 – 44841

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IO1X-ray2.00A54-450[»]
1P95model-A57-451[»]
1UCUelectron microscopy4.00A2-494[»]
3A5Xelectron microscopy4.00A2-495[»]
DisProtiDP00026.
ProteinModelPortaliP06179.
SMRiP06179. Positions 2-495.

Miscellaneous databases

EvolutionaryTraceiP06179.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1344.
HOGENOMiHOG000255144.
KOiK02406.
OMAiNARELDK.
OrthoDBiEOG6M9DVB.
ProtClustDBiPRK08026.

Family and domain databases

InterProiIPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view]
PfamiPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSiPR00207. FLAGELLIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06179-1 [UniParc]FASTA

« Hide

MAQVINTNSL SLLTQNNLNK SQSALGTAIE RLSSGLRINS AKDDAAGQAI    50
ANRFTANIKG LTQASRNAND GISIAQTTEG ALNEINNNLQ RVRELAVQSA 100
NSTNSQSDLD SIQAEITQRL NEIDRVSGQT QFNGVKVLAQ DNTLTIQVGA 150
NDGETIDIDL KQINSQTLGL DTLNVQQKYK VSDTAATVTG YADTTIALDN 200
STFKASATGL GGTDQKIDGD LKFDDTTGKY YAKVTVTGGT GKDGYYEVSV 250
DKTNGEVTLA GGATSPLTGG LPATATEDVK NVQVANADLT EAKAALTAAG 300
VTGTASVVKM SYTDNNGKTI DGGLAVKVGD DYYSATQNKD GSISINTTKY 350
TADDGTSKTA LNKLGGADGK TEVVSIGGKT YAASKAEGHN FKAQPDLAEA 400
AATTTENPLQ KIDAALAQVD TLRSDLGAVQ NRFNSAITNL GNTVNNLTSA 450
RSRIEDSDYA TEVSNMSRAQ ILQQAGTSVL AQANQVPQNV LSLLR 495
Length:495
Mass (Da):51,612
Last modified:January 23, 2007 - v4
Checksum:i4BD7849FA3B936BA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflicti1271S → N in AAA27072. 1 Publication
Sequence conflicti1331N → S in AAA27072. 1 Publication
Sequence conflicti2151Q → E in AAA27072. 1 Publication
Sequence conflicti261 – 27313GGATS…GGLPA → AVTPATVT in AAA27072. 1 Publication
Sequence conflicti277 – 2848EDVKNVQV → ALSGKMYS in AAA27072. 1 Publication
Sequence conflicti287 – 2915ADLTE → PDSDI in AAA27072. 1 Publication
Sequence conflicti3381N → D in AAA27072. 1 Publication
Sequence conflicti3461N → D in AAA27072. 1 Publication
Sequence conflicti3541D → N in AAA27072. 1 Publication
Sequence conflicti375 – 3773SIG → TID in AAA27072. 1 Publication
Sequence conflicti3821A → N in AAA27072. 1 Publication
Sequence conflicti3871E → A in AAA27072. 1 Publication
Sequence conflicti3901N → D in AAA27072. 1 Publication
Sequence conflicti394 – 3963QPD → EPE in AAA27072. 1 Publication
Sequence conflicti4001A → Q in AAA27072. 1 Publication
Sequence conflicti4031T → K in AAA27072. 1 Publication
Sequence conflicti4481T → S in AAA27072. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11332 Genomic DNA. Translation: AAA27072.1.
D13689 Genomic DNA. Translation: BAA02846.1.
AE006468 Genomic DNA. Translation: AAL20871.1.
X51740 Genomic DNA. Translation: CAA36029.1.
J01801 Genomic DNA. Translation: AAA27074.1.
M33808 Genomic DNA. Translation: AAA27080.1.
Z54217 Genomic DNA. Translation: CAA90950.1.
PIRiA24262.
S16121.
RefSeqiNP_460912.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20871; AAL20871; STM1959.
GeneIDi1253480.
KEGGistm:STM1959.
PATRICi32382477. VBISalEnt20916_2074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11332 Genomic DNA. Translation: AAA27072.1 .
D13689 Genomic DNA. Translation: BAA02846.1 .
AE006468 Genomic DNA. Translation: AAL20871.1 .
X51740 Genomic DNA. Translation: CAA36029.1 .
J01801 Genomic DNA. Translation: AAA27074.1 .
M33808 Genomic DNA. Translation: AAA27080.1 .
Z54217 Genomic DNA. Translation: CAA90950.1 .
PIRi A24262.
S16121.
RefSeqi NP_460912.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IO1 X-ray 2.00 A 54-450 [» ]
1P95 model - A 57-451 [» ]
1UCU electron microscopy 4.00 A 2-494 [» ]
3A5X electron microscopy 4.00 A 2-495 [» ]
DisProti DP00026.
ProteinModelPortali P06179.
SMRi P06179. Positions 2-495.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-43768N.
IntActi P06179. 1 interaction.
MINTi MINT-2831235.
STRINGi 99287.STM1959.

Proteomic databases

PaxDbi P06179.
PRIDEi P06179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20871 ; AAL20871 ; STM1959 .
GeneIDi 1253480.
KEGGi stm:STM1959.
PATRICi 32382477. VBISalEnt20916_2074.

Phylogenomic databases

eggNOGi COG1344.
HOGENOMi HOG000255144.
KOi K02406.
OMAi NARELDK.
OrthoDBi EOG6M9DVB.
ProtClustDBi PRK08026.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1970-MONOMER.
Reactomei REACT_147795. Innate Immune System.
REACT_6900. Immune System.
REACT_75813. Ipaf is activated.

Miscellaneous databases

EvolutionaryTracei P06179.

Family and domain databases

InterProi IPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view ]
Pfami PF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view ]
PRINTSi PR00207. FLAGELLIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "The covalent structure of the phase-1 flagellar filament protein of Salmonella typhimurium and its comparison with other flagellins."
    Joys T.M.
    J. Biol. Chem. 260:15758-15761(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Amino acids responsible for flagellar shape are distributed in terminal regions of flagellin."
    Kanto S., Okino H., Aizawa S., Yamaguchi S.
    J. Mol. Biol. 219:471-480(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Conversion of the Salmonella phase 1 flagellin gene fliC to the phase 2 gene fljB on the Escherichia coli K-12 chromosome."
    Okazaki N., Matsuo S., Saito K., Tominaga A., Enomoto M.
    J. Bacteriol. 175:758-766(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
    McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.
    , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
    Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  5. "Flagellar hook and hook-associated proteins of Salmonella typhimurium and their relationship to other axial components of the flagellum."
    Homma M., Derosier D.J., Macnab R.M.
    J. Mol. Biol. 213:819-832(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  6. "Analysis of the nucleotide sequence of an invertible controlling element."
    Zieg J., Simon M.
    Proc. Natl. Acad. Sci. U.S.A. 77:4196-4200(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
  7. "Sequence invariance of the antigen-coding central region of the phase 1 flagellar filament gene (fliC) among strains of Salmonella typhimurium."
    Smith N.H., Selander R.K.
    J. Bacteriol. 172:603-609(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 145-428.
  8. "Point mutations that lock Salmonella typhimurium flagellar filaments in the straight right-handed and left-handed forms and their relation to filament superhelicity."
    Hyman H.C., Trachtenberg S.
    J. Mol. Biol. 220:79-88(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-495.
  9. "The flagellin N-methylase gene fliB and an adjacent serovar-specific IS200 element in Salmonella typhimurium."
    Burnens A.P., Stanley J., Sack R., Hunziker P., Brodard I., Nicolet J.
    Microbiology 143:1539-1547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 476-495.
    Strain: LT2 / ATCC 23564.
  10. "EAL domain protein YdiV acts as an anti-FlhD4C2 factor responsible for nutritional control of the flagellar regulon in Salmonella enterica Serovar Typhimurium."
    Wada T., Morizane T., Abo T., Tominaga A., Inoue-Tanaka K., Kutsukake K.
    J. Bacteriol. 193:1600-1611(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry nameiFLIC_SALTY
AccessioniPrimary (citable) accession number: P06179
Secondary accession number(s): P97160, Q02871, Q56088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes, fliC and fljB.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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