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Reviewed, UniProtKB/Swiss-Prot P06332 (CD4_MOUSE)

Last modified November 25, 2008. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-cell surface glycoprotein CD4
Alternative name(s):
    T-cell surface antigen T4/Leu-3
    T-cell differentiation antigen L3T4
    CD_antigen=CD4
Gene names
Name: Cd4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.

Subunit structure

Associates with p56-LCK. Interacts with SPG21 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

LckP062402EBI-1404,EBI-1401

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P06332-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P06332-2)

Also known as: Brain-specific;

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 457431T-cell surface glycoprotein CD4
PRO_0000014627

Regions

Topological domain27 – 394368Extracellular Potential
Transmembrane395 – 41723 Potential
Topological domain418 – 45740Cytoplasmic Potential
Domain27 – 128102Ig-like V-type
Domain129 – 20779Ig-like C2-type 1
Domain208 – 317110Ig-like C2-type 2
Domain318 – 37457Ig-like C2-type 3

Amino acid modifications

Lipidation4181S-palmitoyl cysteine By similarity
Lipidation4211S-palmitoyl cysteine By similarity
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 112
Disulfide bond159 ↔ 188
Disulfide bond328 ↔ 370

Natural variations

Alternative sequence1 – 240240Missing in isoform 2.
VSP_002489

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 1B1DA7527CB00F33

FASTA45751,297
        10         20         30         40         50         60 
MCRAISLRRL LLLLLQLSQL LAVTQGKTLV LGKEGESAEL PCESSQKKIT VFTWKFSDQR 

        70         80         90        100        110        120 
KILGQHGKGV LIRGGSPSQF DRFDSKKGAW EKGSFPLIIN KLKMEDSQTY ICELENRKEE 

       130        140        150        160        170        180 
VELWVFKVTF SPGTSLLQGQ SLTLTLDSNS KVSNPLTECK HKKGKVVSGS KVLSMSNLRV 

       190        200        210        220        230        240 
QDSDFWNCTV TLDQKKNWFG MTLSVLGFQS TAITAYKSEG ESAEFSFPLN FAEENGWGEL 

       250        260        270        280        290        300 
MWKAEKDSFF QPWISFSIKN KEVSVQKSTK DLKLQLKETL PLTLKIPQVS LQFAGSGNLT 

       310        320        330        340        350        360 
LTLDKGTLHQ EVNLVVMKVA QLNNTLTCEV MGPTSPKMRL TLKQENQEAR VSEEQKVVQV 

       370        380        390        400        410        420 
VAPETGLWQC LLSEGDKVKM DSRIQVLSRG VNQTVFLACV LGGSFGFLGF LGLCILCCVR 

       430        440        450 
CRHQQRQAAR MSQIKRLLSE KKTCQCPHRM QKSHNLI

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Isoform 2 (Brain-specific) [UniParc].

Checksum: 53589C44281646C5
Show »

21724,473

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References

« Hide 'large scale' references
[1]"Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain."
Tourvieille B., Gorman S.D., Field E.H., Hunkapiller T., Parnes J.R.
Science 234:610-614(1986) [PubMed: 3094146] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene."
Littman D.R., Gettner S.N.
Nature 325:453-455(1987) [PubMed: 3027575] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system."
Parnes J.R., Hunkapiller T.
Immunol. Rev. 100:109-127(1987) [PubMed: 3326818] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
[4]"Structure of the mouse gene encoding CD4 and an unusual transcript in brain."
Gorman S.D., Tourvieille B., Parnes J.R.
Proc. Natl. Acad. Sci. U.S.A. 84:7644-7648(1987) [PubMed: 2823269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
Tissue: Brain.
[5]"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6."
Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J., Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.
Genome Res. 8:29-40(1998) [PubMed: 9445485] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Mammary gland.
[7]"The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like."
Classon B.J., Tsagaratos J., Kirszbaum L., Maddox J., McKay C.R., Brandon M., McKenzie I.F.C., Walker I.D.
Immunogenetics 23:129-132(1986) [PubMed: 3082751] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-43.
[8]"Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds."
Classon B.J., Tsagaratos J., McKenzie I.F.C., Walker I.D.
Proc. Natl. Acad. Sci. U.S.A. 83:4499-4503(1986) [PubMed: 3086886] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M36850 mRNA. Translation: AAA39401.1.
M13816 mRNA. Translation: AAA37267.1.
X04836 mRNA. Translation: CAA28539.1.
M36851 Genomic DNA. Translation: AAA39402.1.
M17080, M17078, M17079 Genomic DNA. Translation: AAA37403.1.
AC002397 Genomic DNA. Translation: AAC36010.1.
BC039137 mRNA. Translation: AAH39137.1.
PIRRWMST4. A02110.
RefSeqNP_038516.1.
UniGeneMm.2209

3D structure databases

HSSPHSSP built from PDB template 1CID based on UniProtKB P05540.
ModBaseSearch...

Protein-protein interaction databases

IntActP06332.

PTM databases

PhosphoSiteP06332.

Genome annotation databases

EnsemblENSMUSG00000023274. Mus musculus. [Contig view]
GeneID12504.
KEGGmmu:12504.

Organism-specific databases

MGIMGI:88335. Cd4.

Phylogenomic databases

HOGENOMP06332.
HOVERGENP06332.

Gene expression databases

ArrayExpressP06332.
CleanExMM_CD4.
GermOnlineENSMUSG00000023274. Mus musculus.

Family and domain databases

InterProIPR000973. Ag_CD4.
IPR015274. CD4-extracel.
IPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR003599. Ig_sub.
IPR003596. Ig_V-set_sub.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 4 hits.
PfamPF05790. C2-set. 2 hits.
PF09191. CD4-extracel. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
PRINTSPR00692. CD4TCANTIGEN.
SMARTSM00409. IG. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio281462.
SOURCESearch...

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Entry information

Entry nameCD4_MOUSE
AccessionPrimary (citable) accession number: P06332
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 25, 2008
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents