Reviewed, UniProtKB/Swiss-Prot P06566 (GUN1_BACS4)

Names and origin

Protein names

Recommended name:
    Endoglucanase A
    EC=3.2.1.4
Alternative name(s):
    Endo-1,4-beta-glucanase A
    Cellulase A

Gene names

Name:

celA

Organism

Bacillus sp. (strain N-4 / JCM 9156)

Taxonomic identifier

1413 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Sequence similarities	Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cellulose degradation Polysaccharide degradation
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro cation binding Inferred from electronic annotation. Source: InterPro cellulase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Endoglucanase A		PRO_0000184044
Sites
	Active site	163	1	Proton donor By similarity
	Active site	252	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06566-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 97248E453D28D3B5	FASTA	488	54,264
	10 20 30 40 50 60 MKKLTTIFIV FTLALLFVGN STSANNGSVV EQNGQLSIQN GQLVNEHGDP VQLKGMSSHG 70 80 90 100 110 120 LQWYGQFVNY DSIKWLRDDW GITVFRAAMY TSSGGYIEDP SVKEKVKEAV EAAIDLGIYV 130 140 150 160 170 180 IIDWHILSDN DPNIYKEEAK EFFDEMSALY GDYPNVIYEI ANEPNGHNVR WDSHIKPYAE 190 200 210 220 230 240 EVIPVIRAND PNNIVIVGTA TWSQDVHEAA DNQLDDPNVM YAFHFYAGTH GQQLRNQVDY 250 260 270 280 290 300 ALSRGAAIFV SEWGTSAATG DGGVFLDEAQ VWIDFMDERN LSWANWSLTH KDESSAALMP 310 320 330 340 350 360 GANPTGGWTA AELSPSGAFV REKIRESASI PPSDPTPPSD PDPGEPDPTP PSDPGEYPAW 370 380 390 400 410 420 DPNQIYTNEI VYHNGQLWQA KWWTQNQEPG ANQYGPWEPL GDAPPSEPSD PPPPSEPEPD 430 440 450 460 470 480 PGEPDPGEPD PGEPDPTPPS DPGEYPAWDP TQIYTNEIVY HNGQLWQAKW WTQNQEPGYP YGPWEPLN

References

[1]	"Nucleotide sequences of two cellulase genes from alkalophilic Bacillus sp. strain N-4 and their strong homology." Fukumori F., Sashihara N., Kudo T., Horikoshi K. J. Bacteriol. 168:479-485(1986) [PubMed: 3782013] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M14781 Genomic DNA. Translation: AAA22301.1.
PIR	A25156.
3D structure databases
HSSP	HSSP built from PDB template 1LF1 based on UniProtKB Q59232.
SMR	P06566. Positions 28-328.
ModBase	Search...
Family and domain databases
InterPro	IPR003610. CBM_5_12. IPR001547. Glyco_hydro_5. IPR013781. Glyco_hydro_sub_cat. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF02839. CBM_5_12. 2 hits. PF00150. Cellulase. 1 hit. [Graphical view]
SMART	SM00495. ChtBD3. 2 hits. [Graphical view]
PROSITE	PS00659. GLYCOSYL_HYDROL_F5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUN1_BACS4

Accession

Primary (citable) accession number: P06566

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)