Reviewed, UniProtKB/Swiss-Prot P07311 (ACYP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-1
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 1
    Acylphosphatase, organ-common type isozyme
    Acylphosphatase, erythrocyte isozyme

Gene names

Name:	ACYP1
Synonyms:	ACYPE

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H(2)O = a carboxylate + phosphate.
Tissue specificity	Organ-common type isozyme is found in many different tissues.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	phosphate metabolic process Ref.4 Traceable author statement. Source: ProtInc
Molecular function	acylphosphatase activity Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 99	98	Acylphosphatase-1
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine
Experimental info
	Sequence conflict	20	1	G → R Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P07311-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F9F787E490BC8296	FASTA	99	11,261
	10 20 30 40 50 60 MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR 70 80 90 HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Raugei G. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[4]	"A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure." Liguri G., Camici G., Manao G., Cappugi G., Nassi P., Modesti A., Ramponi G. Biochemistry 25:8089-8094(1986) [PubMed: 3026468] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99.
[5]	"Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase." Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G. FEBS Lett. 367:145-148(1995) [PubMed: 7796909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-86. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X84194 mRNA. Translation: CAA58987.1. AC007055 Genomic DNA. Translation: AAD31937.1. BC035568 mRNA. Translation: AAH35568.1.
PIR	QPHUE. S66187.
RefSeq	NP_001098.1. NP_982355.1.
UniGene	Hs.18573
3D structure databases
HSSP	HSSP built from PDB template 2ACY based on UniProtKB P41500.
SMR	P07311. Positions 2-99.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000119640. Homo sapiens. [Contig view]
GeneID	97.
KEGG	hsa:97.
Organism-specific databases
H-InvDB	HIX0026751. HIX0074267.
HGNC	HGNC:179. ACYP1.
MIM	600875. gene.
PharmGKB	PA24499.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P07311.
HOVERGEN	P07311.
Gene expression databases
ArrayExpress	P07311.
CleanEx	HS_ACYP1.
GermOnline	ENSG00000119640. Homo sapiens.
Family and domain databases
InterPro	IPR001792. Acylphosphatase. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
ProDom	PD001884. Acylphosphatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ACYP1_HUMAN

Accession

Primary (citable) accession number: P07311

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)