Reviewed, UniProtKB/Swiss-Prot P07828 (ACT18_DICDI)

Names and origin

Protein names

Recommended name:
    Actin-18
Alternative name(s):
    Actin-3-sub 2

Gene names

Name:	act18
Synonyms:	act3-2
ORF Names:	DDB_0220459

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction By similarity.
Subcellular location	Cytoplasm › cytoskeletonBy similarity.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Structural protein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 380	379	Actin-18
Experimental info
	Sequence conflict	56	1	G → V in CAA27034. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P07828-1 [UniParc]. Last modified December 4, 2007. Version 3. Checksum: 6C3FA2D27E23F286	FASTA	380	42,532
	10 20 30 40 50 60 MEREEVQAIV IDNGSDMCKA GFAGDDAPRA VFQSIVGRPR YTGVMDVMGQ KDSYIGDEAH 70 80 90 100 110 120 SRKGFLTLKY PIERGIVTNW DDMEEIWHHT FYNELGVAPE EHPVLLTEQP LNPKKNREKM 130 140 150 160 170 180 TQIMFETFNT PAMYVAIQAV LSLYSSGRTT GIVMDSGDGV SHAVSIYEGH ALPHAILRLD 190 200 210 220 230 240 LAGRDLSDYM MKILTKRGYS FTTTAEKEII KDIKEKLSYV ALDFDAEMLT AASSTTLEKS 250 260 270 280 290 300 YELPDGKVIT IGNERFRCPE ALFQPSLLAM ESAGIHETIY NSIMKCDVDI RRYLFGNVIL 310 320 330 340 350 360 SGGSTMFPGI ADRMNKELTA LAPSTMKIKI IAPPERKYSV WVGGSILASL SSFQEMWISK 370 380 EEYNESGPSI VHRKCSNYLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of the actin multigene family of Dictyostelium discoideum and analysis of variability in the protein coding regions." Romans P., Firtel R.A. J. Mol. Biol. 186:321-335(1985) [PubMed: 3003365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X03284 Genomic DNA. Translation: CAA27034.1. AAFI02000141 Genomic DNA. Translation: EAL62676.1.
PIR	D23412.
RefSeq	XP_636193.1.
3D structure databases
HSSP	HSSP built from PDB template 1NM1 based on UniProtKB P02577.
SMR	P07828. Positions 5-373.
ModBase	Search...
Genome annotation databases
GeneID	3387753.
KEGG	ddi:DDB_0220459.
Organism-specific databases
dictyBase	DDB0220459. act18.
Family and domain databases
InterPro	IPR004001. Actin_CS. IPR004000. Actin_like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProDom	P07828. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACT18_DICDI

Accession

Primary (citable) accession number: P07828
Secondary accession number(s): Q54HE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	December 4, 2007
Last modified:	July 22, 2008
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)