Neprilysin - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Neprilysin
    EC=3.4.24.11
Alternative name(s):
    Neutral endopeptidase 24.11
      Short name(s)=Neutral endopeptidase, NEP
    Enkephalinase
    Atriopeptidase
    Common acute lymphocytic leukemia antigen
      Short name(s)=CALLA
    CD_antigen=CD10

Gene names

Name:	MME
Synonyms:	EPN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	750 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).
Catalytic activity	Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
Cofactor	Binds 1 zinc ion per subunit.
Enzyme regulation	Inhibited in a dose dependent manner by opiorphin.
Subcellular location	Membrane; Single-pass type II membrane protein.
Involvement in disease	Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.
Sequence similarities	Belongs to the peptidase M13 family.

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Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell-cell signaling Traceable author statement. Source: ProtInc proteolysis Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	metallopeptidase activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...