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Reviewed, UniProtKB/Swiss-Prot P09092 (HXA6_MOUSE)

Last modified September 2, 2008. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A6
Alternative name(s):
    Hox-1.2
    M5-4
Gene names
Name: Hoxa6
Synonyms: Hox-1.2, Hoxa-6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein

Gene Ontology (GO)

   Biological processanterior/posterior pattern formation

Inferred from mutant phenotype. Source: MGI

embryonic skeletal morphogenesis

Inferred from mutant phenotype. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 232232Homeobox protein Hox-A6

Regions

DNA binding154 – 21360Homeobox
Motif135 – 1406Antp-type hexapeptide

Experimental info

Sequence conflict136 – 14611YPWMQRMNSCA → ASLIRTSFLPT Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P09092-1 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 7E29499428BBA8A7

FASTA23226,335
        10         20         30         40         50         60 
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ 

        70         80         90        100        110        120 
SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG DYLHFSPEQQ YKPDGSVQGK 

       130        140        150        160        170        180 
ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY GSHGRRGRQT YTRYQTLELE KEFHFNRYLT 

       190        200        210        220        230 
RRRRIEIANA LCLTERQIKI WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE

« Hide

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References

[1]"Mouse Hoxa6 gene structure and regulation."
Tan D.P., Shao X., Peterkofsky A.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ICR X Swiss Webster.
Tissue: Liver.
[2]"Clustered homeo boxes are differentially expressed during murine development."
Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F., Gruss P.
Cell 43:39-45(1985) [PubMed: 2416462] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF247663 Genomic DNA. Translation: AAF97512.1.
M11988 Genomic DNA. Translation: AAA37830.1.
PIRA24779.
RefSeqNP_034584.1.
UniGeneMm.222030

3D structure databases

HSSPHSSP built from PDB template 1HOM based on UniProtKB P02833.
SMRP09092. Positions 155-214.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000043219. Mus musculus. [Contig view]
GeneID15403.
KEGGmmu:15403.

Organism-specific databases

MGIMGI:96178. Hoxa6.

Phylogenomic databases

HOGENOMP09092.
HOVERGENP09092.

Gene expression databases

ArrayExpressP09092.
CleanExMM_HOXA6.
GermOnlineENSMUSG00000043219. Mus musculus.

Family and domain databases

InterProIPR001827. Antennapedia.
IPR001356. Homeobox.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameHXA6_MOUSE
AccessionPrimary (citable) accession number: P09092
Secondary accession number(s): Q9JI98
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: September 2, 2008
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents