Reviewed, UniProtKB/Swiss-Prot P09564 (CD7_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell antigen CD7
Alternative name(s):
    GP40
    T-cell leukemia antigen
    TP41
    Leu-9
    CD_antigen=CD7

Gene names

Name:

CD7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Not yet known.
Subunit structure	Interacts with SECTM1.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	T cell activation Traceable author statement. Source: UniProtKB immune response Traceable author statement. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Traceable author statement. Source: UniProtKB membrane fraction Ref.1 Traceable author statement. Source: ProtInc plasma membrane Traceable author statement. Source: ProtInc
Molecular function	receptor activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 25	25
	Chain	26 – 240	215	T-cell antigen CD7
Regions
	Topological domain	26 – 180	155	Extracellular Probable
	Transmembrane	181 – 201	21	Probable
	Topological domain	202 – 240	39	Cytoplasmic Probable
	Domain	26 – 130	105	Ig-like
	Repeat	145 – 153	9	1
	Repeat	154 – 162	9	2
	Repeat	163 – 171	9	3
	Repeat	172 – 180	9	4
	Region	145 – 180	36	4 X 9 AA tandem repeats, potential spacer function
Amino acid modifications
	Lipidation	198	1	S-palmitoyl cysteine
	Glycosylation	45	1	N-linked (GlcNAc...)
	Glycosylation	96	1	N-linked (GlcNAc...)
	Disulfide bond	35 ↔ 142		Potential
	Disulfide bond	48 ↔ 114		Potential

Sequences

	Sequence		Length	Mass (Da)
	P09564-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: EBBCE08279552108	FASTA	240	25,409
	10 20 30 40 50 60 MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 70 80 90 100 110 120 QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 130 140 150 160 170 180 NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 190 200 210 220 230 240 AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system." Aruffo A., Seed B. EMBO J. 6:3313-3316(1987) [PubMed: 3501369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene." Schanberg L.E., Fleenor D.E., Kurtzberg J., Haynes B.F., Kaufman R.E. Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed: 1703303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"Molecular cloning of the gene coding for the human T cell differentiation antigen CD7." Yoshikawa K., Seto M., Ueda R., Obata Y., Notake K., Yokochi T., Takahashi T. Immunogenetics 33:352-360(1991) [PubMed: 1711009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-240.
[6]	"Characterization of the surface topography and putative tertiary structure of the human CD7 molecule." Ware R.E., Scearce R.M., Dietz M.A., Starmer C.F., Palker T.J., Haynes B.F. J. Immunol. 143:3632-3640(1989) [PubMed: 2479685] [Abstract] Cited for: TOPOLOGY.
[7]	"Identification of CD7 as a cognate of the human K12 (SECTM1) protein." Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C. J. Biol. Chem. 275:3431-3437(2000) [PubMed: 10652336] [Abstract] Cited for: INTERACTION WITH SECTM1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X06180 mRNA. Translation: CAA29546.1. M37271 Genomic DNA. Translation: AAA51953.1. BT006696 mRNA. Translation: AAP35342.1. BC009293 mRNA. Translation: AAH09293.1. BC013297 mRNA. Translation: AAH13297.1. D00749 Genomic DNA. Translation: BAA00646.1.
PIR	A39016.
RefSeq	NP_006128.1.
UniGene	Hs.36972
3D structure databases
HSSP	HSSP built from PDB template 1BWW based on UniProtKB P01607.
ModBase	Search...
PTM databases
PhosphoSite	P09564.
Genome annotation databases
Ensembl	ENSG00000173762. Homo sapiens. [Contig view]
GeneID	924.
KEGG	hsa:924.
Organism-specific databases
H-InvDB	HIX0014252.
HGNC	HGNC:1695. CD7.
HPA	CAB002594.
MIM	186820. gene.
PharmGKB	PA26234.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P09564.
HOVERGEN	P09564.
Gene expression databases
ArrayExpress	P09564.
CleanEx	HS_CD7.
GermOnline	ENSG00000173762. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProDom	P09564. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CD7_HUMAN

Accession

Primary (citable) accession number: P09564

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	July 22, 2008
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)