Reviewed, UniProtKB/Swiss-Prot P09635 (HXA4_RAT)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A4
Alternative name(s):
    Homeobox protein R2

Gene names

Name:	Hoxa4
Synonyms:	Hox-a4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	67 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – ›67	›67	Homeobox protein Hox-A4
Regions
	DNA binding	‹1 – 42	›42	Homeobox
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	67	1

Sequences

	Sequence		Length	Mass (Da)
	P09635-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 5BFDFEAE93193780	FASTA	67	8,346
	10 20 30 40 50 60 EFHFNRYLTR RRRIEIAHTL CLSERQVKIW FQNRRMKWKK DHKLPNTRCD LPTLPRPLPA RLGKHKL

References

[1]	"Cloning and expression of rat homeo-box-containing sequences." Falzon M., Sanderson N., Chung S.Y. Gene 54:23-32(1987) [PubMed: 2886401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
[2]	"Cloning of rat homeobox genes." Sakoyama Y., Mizuta I., Ogasawara N., Yoshikawa H. Biochem. Genet. 32:351-360(1994) [PubMed: 7702549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M16808 Genomic DNA. No translation available. S76296 Genomic DNA. No translation available.
PIR	B27471.
UniGene	Rn.8465
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ModBase	Search...
Organism-specific databases
RGD	2814. Hoxa4.
Phylogenomic databases
HOVERGEN	P09635.
Family and domain databases
InterPro	IPR001827. Antennapedia. IPR001356. Homeobox. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. Partial match. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HXA4_RAT

Accession

Primary (citable) accession number: P09635

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	July 22, 2008
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)