true
2005-03-01
2008-07-22
25
DYR_STAAM
DYRB_STAAM
Dihydrofolate reductase
DHFR
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Kuroda M.
Ohta T.
Uchiyama I.
Baba T.
Yuzawa H.
Kobayashi I.
Cui L.
Oguchi A.
Aoki K.
Nagai Y.
Lian J.-Q.
Ito T.
Kanamori M.
Matsumaru H.
Maruyama A.
Murakami H.
Hosoyama A.
Mizutani-Ui Y.
Takahashi N.K.
Sawano T.
Inoue R.
Kaito C.
Sekimizu K.
Hirakawa H.
Kuhara S.
Goto S.
Yabuzaki J.
Kanehisa M.
Yamashita A.
Oshima K.
Furuya K.
Yoshino C.
Shiba T.
Hattori M.
Ogasawara N.
Hayashi H.
Hiramatsu K.
doi:10.1016/S0140-6736(00)04403-2
2001
Lancet
357
1225-1240
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
folA
SAV1426
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
Cofactor biosynthesis; tetrahydrofolate biosynthesis; tetrahydrofolate from dihydrofolate: step 1/1.
The reaction catalyzed by this enzyme represents an essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Belongs to the dihydrofolate reductase family.
Contains 1 DHFR (dihydrofolate reductase) domain.
Removed
1
1
Dihydrofolate reductase
2
159
DHFR
2
157
EMBL
RefSeq
HSSP
1DHI
World-2DPAGE
GeneID
GenomeReviews
SAV1426
KEGG
HOGENOM
BioCyc
BindingDB
InterPro
DHFR
InterPro
DHFR_reg
PANTHER
DHFR
1
Pfam
DHFR_1
1
PRINTS
DHFR
PROSITE
DHFR_1
1
PROSITE
DHFR_2
1
2007-01-23
2
18251
MTLSILVAHD LQRVIGFENQ LPWHLPNDLK HVKKLSTGHT LVMGRKTFES IGKPLPNRRN VVLTSDTSFN VEGVDVIHSI EDIYQLPGHV FIFGGQTLFE EMIDKVDDMY ITVIEGKFRG DTFFPPYTFE DWEVASSVEG KLDEKNTIPH TFLHLIRKK