SubmitCancel

Skip Header

P0A4H2

- BVGA_BORPE

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here

Protein
Virulence factors putative positive transcription regulator BvgA
Gene
bvgA, BP1878

Gene:

bvgA, BP1878
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - - Experimental evidence at protein leveli

UniProt

P0A4H2 - BVGA_BORPE

Protein:

Virulence factors putative positive transcription regulator BvgA
Protein Existence: Experimental evidence at protein level

Functioni

Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
DNA bindingi166 – 18520H-T-H motif By similarity

GO - Molecular functioni

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
  3. sequence-specific DNA binding transcription factor activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
  3. sequence-specific DNA binding transcription factor activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBPER257313:BP1878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence factors putative positive transcription regulator BvgA
Gene namesi
Name:bvgA
Ordered Locus Names:BP1878
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 209209Virulence factors putative positive transcription regulator BvgA
PRO_0000081034

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Modified residuei5414-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by BvgS.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi257313.BP1878.

Structurei

3D structure databases

ProteinModelPortaliP0A4H2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Domaini1 – 119119Response regulatory
Domaini142 – 20766HTH luxR-type

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2197.
HOGENOMiHOG000034813.
KOiK07690.
OMAiHILLIMY.
OrthoDBiEOG69GZGV.
ProtClustDBiCLSK434910.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4H2-1 [UniParc]FASTA

« Hide

MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL    50
VVLDIGIPKL DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG 100
FVCKHENLHE VINAAKAVMA GYTYFPSTTL SEMRMGDNAK SDSTLISVLS 150
NRELTVLQLL AQGMSNKDIA DSMFLSNKTV STYKTRLLQK LNATSLVELI 200
DLAKRNNLA 209
Length:209
Mass (Da):22,952
Last modified:March 15, 2005 - v1
Checksum:i5D5B32BB2A69B23E
GO

Mass spectrometryi

Molecular mass is 22949 Da from positions 1 - 209. Determined by MALDI.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25401 Genomic DNA. Translation: AAA22969.1.
BX640416 Genomic DNA. Translation: CAE42161.1.
PIRiVZBRGP. B33729.
RefSeqiNP_880570.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42161; CAE42161; BP1878.
GeneIDi2667058.
KEGGibpe:BP1878.
PATRICi21157044. VBIBorPer7866_2017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25401 Genomic DNA. Translation: AAA22969.1 .
BX640416 Genomic DNA. Translation: CAE42161.1 .
PIRi VZBRGP. B33729.
RefSeqi NP_880570.1. NC_002929.2.

3D structure databases

ProteinModelPortali P0A4H2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257313.BP1878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE42161 ; CAE42161 ; BP1878 .
GeneIDi 2667058.
KEGGi bpe:BP1878.
PATRICi 21157044. VBIBorPer7866_2017.

Phylogenomic databases

eggNOGi COG2197.
HOGENOMi HOG000034813.
KOi K07690.
OMAi HILLIMY.
OrthoDBi EOG69GZGV.
ProtClustDBi CLSK434910.

Enzyme and pathway databases

BioCyci BPER257313:BP1878-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
PRINTSi PR00038. HTHLUXR.
SMARTi SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
PROSITEi PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins."
    Arico B., Miller J.F., Roy C., Stibitz S., Monack D.M., Falkow S., Gross R., Rappuoli R.
    Proc. Natl. Acad. Sci. U.S.A. 86:6671-6675(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
  3. "Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis."
    Scarlato V., Prugnola A., Arico B., Rappuoli R.
    Proc. Natl. Acad. Sci. U.S.A. 87:6753-6757(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
  4. "Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade."
    Uhl M.A., Miller J.F.
    Proc. Natl. Acad. Sci. U.S.A. 91:1163-1167(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins."
    Perraud A.-L., Kimmel B., Weiss V., Gross R.
    Mol. Microbiol. 27:875-887(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems."
    Perraud A.-L., Rippe K., Bantscheff M., Glocker M., Lucassen M., Jung K., Sebald W., Weiss V., Gross R.
    Biochim. Biophys. Acta 1478:341-354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MASS SPECTROMETRY.

Entry nameiBVGA_BORPE
AccessioniPrimary (citable) accession number: P0A4H2
Secondary accession number(s): P16574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi