true 1986-07-21 2008-07-22 28 TYSY_ECOL6 Thymidylate synthase TS TSase Welch R.A. Burland V. Plunkett G. III Redford P. Roesch P. Rasko D. Buckles E.L. Liou S.-R. Boutin A. Hackett J. Stroud D. Mayhew G.F. Rose D.J. Zhou S. Schwartz D.C. Perna N.T. Mobley H.L.T. Donnenberg M.S. Blattner F.R. doi:10.1073/pnas.252529799 2002 Proc. Natl. Acad. Sci. U.S.A. 99 17020-17024 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] O6:H1 / CFT073 / ATCC 700928 / UPEC thyA c3422 Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation (By similarity). 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. Pyrimidine metabolism; dTTP biosynthesis. Homodimer (By similarity). The N-terminus is carboxylated (By similarity). Belongs to the thymidylate synthase family. Thymidylate synthase 1 264 146 146 EMBL RefSeq GeneID GenomeReviews c3422 KEGG HOGENOM BindingDB HAMAP 1 InterPro Thymidylat_synth_C Gene3D Thymidylat_synth_C 1 PANTHER Thymidylat_synth_C 1 Pfam Thymidylat_synt 1 PRINTS THYMDSNTHASE ProDom Thymidylat_synth 1 TIGRFAMs thym_sym 1 PROSITE THYMIDYLATE_SYNTHASE 1 HAMAP HAMAP HAMAP 1986-07-21 1 30480 MKQYLELMQK VLDEGTQKND RTGTGTLSIF GHQMRFNLQD GFPLVTTKRC HLRSIIHELL WFLQGDTNIA YLHENNVTIW DEWADENGDL GPVYGKQWRA WPTPDGRHID QITTVLNQLK NDPDSRRIIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS YALLVHMMAQ QCDLEVGDFV WTGGDTHLYS NHMDQTHLQL SREPRPLPKL IIKRKPESIF DYRFEDFEIE GYDPHPGIKA PVAI