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P0ABH0

- FTSA_ECOLI

UniProt

P0ABH0 - FTSA_ECOLI

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Protein
Cell division protein FtsA
Gene
ftsA, divA, b0094, JW0092
Organism
Escherichia coli (strain K12)
Status
Reviewed - - Experimental evidence at protein leveli

Functioni

This protein may be involved in anomalous filament growth By similarity. May be a component of the septum.

GO - Molecular functioni

  1. ATP bindingInferred from direct assayi PubMed 19297332 Source: EcoCyc
  2. identical protein bindingInferred from physical interactioni PubMed 15774864PubMed 17986188PubMed 18186792PubMed 18394147 Source: IntAct
  3. protein bindingInferred from physical interactioni PubMed 15774864PubMed 17986188PubMed 18186792PubMed 18394147PubMed 19415799PubMed 22328664 Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cell cycleInferred from electronic annotationi Source: UniProtKB-KW
  2. cell divisionInferred from mutant phenotypei PubMed 4583216PubMed 8917533 Source: EcoliWiki
  3. regulation of cell shapeInferred from electronic annotationi Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10339-MONOMER.
ECOL316407:JW0092-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsA
Gene namesi
Name:ftsA
Synonyms:divA
Ordered Locus Names:b0094, JW0092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10339. ftsA.

Subcellular locationi

GO - Cellular componenti

  1. cell division siteInferred from direct assayi PubMed 8917533 Source: EcoliWiki
  2. cytoplasmic side of plasma membraneInferred from direct assayi PubMed 2203741 Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 420420Cell division protein FtsA
PRO_0000062734

Proteomic databases

PaxDbiP0ABH0.
PRIDEiP0ABH0.

Expressioni

Gene expression databases

GenevestigatoriP0ABH0.

Interactioni

Subunit structurei

Interacts with FtsZ By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-550562,EBI-550562
ftsNP291317EBI-550562,EBI-1134233
ftsZP0A9A66EBI-550562,EBI-370963

Protein-protein interaction databases

DIPiDIP-47983N.
IntActiP0ABH0. 26 interactions.
STRINGi511145.b0094.

Structurei

3D structure databases

ProteinModelPortaliP0ABH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsA/MreB family.

Phylogenomic databases

eggNOGiCOG0849.
HOGENOMiHOG000049205.
KOiK03590.
OMAiIEDPLGM.
OrthoDBiEOG6TR0B6.
PhylomeDBiP0ABH0.

Family and domain databases

InterProiIPR020823. Cell_div_FtsA.
IPR003494. SHS2_FtsA.
[Graphical view]
PfamiPF02491. SHS2_FTSA. 1 hit.
[Graphical view]
PIRSFiPIRSF003101. FtsA. 1 hit.
SMARTiSM00842. FtsA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01174. ftsA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABH0-1 [UniParc]FASTA

« Hide

MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG    50
VNDLESVVKC VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS 100
EEEVTQEDVE NVVHTAKSVR VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS 150
GVRMQAKVHL ITCHNDMAKN IVKAVERCGL KVDQLIFAGL ASSYSVLTED 200
ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT SDIAYAFGTP 250
PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR 300
YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR 350
VFHTQVRIGA PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR 400
VTASVGSWIK RLNSWLRKEF 420
Length:420
Mass (Da):45,330
Last modified:January 1, 1988 - v1
Checksum:iC2475377A229B982
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflicti339 – 3391A → R1 Publication
Sequence conflicti339 – 3391A → R1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02668 Genomic DNA. Translation: AAA23817.1.
M36531 Genomic DNA. Translation: AAA23811.1.
X55034 Genomic DNA. Translation: CAA38871.1.
U00096 Genomic DNA. Translation: AAC73205.1.
AP009048 Genomic DNA. Translation: BAB96662.1.
PIRiCEECA. B23318.
RefSeqiNP_414636.1. NC_000913.3.
YP_488399.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73205; AAC73205; b0094.
BAB96662; BAB96662; BAB96662.
GeneIDi12932892.
944778.
KEGGiecj:Y75_p0093.
eco:b0094.
PATRICi32115293. VBIEscCol129921_0098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02668 Genomic DNA. Translation: AAA23817.1 .
M36531 Genomic DNA. Translation: AAA23811.1 .
X55034 Genomic DNA. Translation: CAA38871.1 .
U00096 Genomic DNA. Translation: AAC73205.1 .
AP009048 Genomic DNA. Translation: BAB96662.1 .
PIRi CEECA. B23318.
RefSeqi NP_414636.1. NC_000913.3.
YP_488399.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0ABH0.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-47983N.
IntActi P0ABH0. 26 interactions.
STRINGi 511145.b0094.

Proteomic databases

PaxDbi P0ABH0.
PRIDEi P0ABH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73205 ; AAC73205 ; b0094 .
BAB96662 ; BAB96662 ; BAB96662 .
GeneIDi 12932892.
944778.
KEGGi ecj:Y75_p0093.
eco:b0094.
PATRICi 32115293. VBIEscCol129921_0098.

Organism-specific databases

EchoBASEi EB0335.
EcoGenei EG10339. ftsA.

Phylogenomic databases

eggNOGi COG0849.
HOGENOMi HOG000049205.
KOi K03590.
OMAi IEDPLGM.
OrthoDBi EOG6TR0B6.
PhylomeDBi P0ABH0.

Enzyme and pathway databases

BioCyci EcoCyc:EG10339-MONOMER.
ECOL316407:JW0092-MONOMER.

Miscellaneous databases

PROi P0ABH0.

Gene expression databases

Genevestigatori P0ABH0.

Family and domain databases

InterProi IPR020823. Cell_div_FtsA.
IPR003494. SHS2_FtsA.
[Graphical view ]
Pfami PF02491. SHS2_FTSA. 1 hit.
[Graphical view ]
PIRSFi PIRSF003101. FtsA. 1 hit.
SMARTi SM00842. FtsA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01174. ftsA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units."
    Robinson A.C., Kenan D.J., Hatfull G.F., Sullivan N.F., Spiegelberg R., Donachie W.D.
    J. Bacteriol. 160:546-555(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Structure and expression of the cell division genes ftsQ, ftsA and ftsZ."
    Yi Q.-M., Rockenbach S., Ward J.E. Jr., Lutkenhaus J.
    J. Mol. Biol. 184:399-412(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. "Mapping and characterization of mutants of the Escherichia coli cell division gene, ftsA."
    Robinson A.C., Begg K.J., Sweeney J., Condie A., Donachie W.D.
    Mol. Microbiol. 2:581-588(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTANTS TEMPERATURE-SENSITIVE.
  4. "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region."
    Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.
    Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12.
  5. "The complete genome sequence of Escherichia coli K-12."
    Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
    Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "Regulation of expression of the ftsA cell division gene by sequences in upstream genes."
    Dewar S.J., Donachie W.D.
    J. Bacteriol. 172:6611-6614(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
  8. "The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli."
    Yi Q.-M., Lutkenhaus J.
    Gene 36:241-247(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-420.
    Strain: K12.

Entry nameiFTSA_ECOLI
AccessioniPrimary (citable) accession number: P0ABH0
Secondary accession number(s): P06137, Q47229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

External Data

Dasty 3

Similar proteinsi