true
2008-01-15
2008-03-18
3
HBEAG_HBVA3
External core antigen precursor
HBeAg
Precore protein
p25
The nucleotide sequence of the hepatitis B viral genome and the identification of the major viral genes.
Valenzuela P.
Quiroga M.
Zaldivar J.
Gray P.
Rutter W.J.
1980
Field B.N.
Jaenisch R.
Fox C.F.
Animal virus genetics
57-70
Academic Press
New York
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
Proteaselike sequence in hepatitis B virus core antigen is not required for e antigen generation and may not be part of an aspartic acid-type protease.
Nassal M.
Galle P.R.
Schaller H.
1989
J. Virol.
63
2598-2604
CLEAVAGE BY HOST
Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide.
Ou J.H.
Yeh C.T.
Yen T.S.
1989
J. Virol.
63
5238-5243
NUCLEAR LOCALIZATION
Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen.
Yuan T.T.
Tai P.C.
Shih C.
1999
J. Virol.
73
10122-10128
VARIANT LEU-126
C
May regulate immune response to the intracellular capsid in acting as a T cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections (By similarity).
Homodimerizes.
Secreted. Nucleus.
Phosphorylated.
Cleaved by host furin (By similarity).
Belongs to the orthohepadnavirus precore antigen family.
1
19
External core antigen
20
185
186
214
1; half-length
186
192
2
193
200
3
201
208
3 X 8 AA repeats of S-P-R-R-R-R-S-[PQ]
186
208
Cleavage by host
185
186
Interchain
77
77
Interchain
90
90
M
122
122
Frequent mutation in chronic HBV carriers.
L
126
126
P
198
198
HepSEQ; Hepatitis virus B database
EMBL
InterPro
Vir_capsid_Znf-put_N_Hepatitis
InterPro
Viral_capsid_core_Hepatitis
Pfam
Hep_core_N
1
Pfam
Hepatitis_core
1
2008-01-15
1
24580
External core antigen
MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGNNLEDPAS RDLVVNYVNT NVGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR RDRGRSPRRR TPSPRRRRSP SPRRRRSQSR ESQC
Capsid protein