Reviewed, UniProtKB/Swiss-Prot P10334 (MS2B_DROME)

Names and origin

Protein names

Recommended name:
    Accessory gland-specific peptide 26Ab
Alternative name(s):
    Male accessory gland secretory protein 355B

Gene names

Name:	Acp26Ab
Synonyms:	Mst26Ab, mst355b
ORF Names:	CG9024

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is transferred from male to female during mating and may affect egglaying and behavior after mating.
Subcellular location	Secreted › extracellular space.
Tissue specificity	Main cells of the accessory glands of males.

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 90	69	Accessory gland-specific peptide 26Ab
Natural variations
	Natural variant	64	1	Q → H in strain: AF1, AF2, AF3, AF5, AF6, AF7, AF8, AF9, AF10, Au4, Au7, Au8, La3, La10, La13, La14, La15, La28, La31, La32, La36, La37, La54, La58, La60, La62, La105, La106, La116, La118, La120, La125, Ma3, Ma6, Ma11, Ma18, Ma20, Ma21, Ma23, Ma24, Ma31, Ma35, Ma37, Ma43, Ma50, Ma53, Ma56, Ma57, Ma60, Ma74, Mo29b, Mo40b, Mo52b, NC-003, NC-004, NC-006, NC-008, NC-009, Ny2, Ny3, Ny4, Ny5, TW1, TW2, TW5, TW6, TW7, TW8, TW10 and TW11.
	Natural variant	77	1	P → R in strain: TW9.
	Natural variant	80	1	I → V in strain: La3, La10, La13, La15, La27, La28, La31, La62, La105, La106, La116, La118, La120, Ma3, Ma6, Ma18, Ma23, Ma31, Ma37, Ma43, Ma56, Ma57, Ma60, Ma74, Mo13a, Mo29b, Mo34a, Mo40b, Mo52b, NC-002, NC-003, NC-004, NC-006, NC-008, Ny2, Ny4, TW2, TW4, TW5, TW8, TW10 and TW11.
	Natural variant	89	1	M → I in strain: Au4 and Ma60.
	Natural variant	90	1	A → E in strain: AF1, AF2, AF3, AF5, AF6, AF7, AF8, AF9, AF10, La14, La31, La32, La60, La106, La118, La125, Ma6, Ma21, Ma24, Ma31, Ma37, Ma50, Ma56, Ma57, Ma74, TW1 and TW6.

Sequences

	Sequence		Length	Mass (Da)
	P10334-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 1FDFDC7951F9BDFF	FASTA	90	10,162
	10 20 30 40 50 60 MNYFAVICIF SCICLWQFSD AAPFISVQSS SQSRSQKVMN GMLRTLYDYS VQDSVNDATG 70 80 90 HLIQTHKADF NSDVMSPDEI ESVRQQLNMA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of a Drosophila male accessory gland gene whose product resembles a peptide pheromone precursor." Monsma S.A., Wolfner M.F. Genes Dev. 2:1063-1073(1988) [PubMed: 3142802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[2]	"Polymorphism and divergence in the Mst26A male accessory gland gene region in Drosophila." Aguade M., Miyashita N., Langley C.H. Genetics 132:755-770(1992) [PubMed: 1361475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NC-001, NC-002, NC-003, NC-004, NC-005, NC-006, NC-007, NC-008, NC-009 and NC-010.
[3]	"Different forces drive the evolution of the Acp26Aa and Acp26Ab accessory gland genes in the Drosophila melanogaster species complex." Aguade M. Genetics 150:1079-1089(1998) [PubMed: 9799260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-64; VAL-80; ILE-89 AND GLU-90. Strain: La10, La105, La106, La108, La116, La118, La120, La125, La13, La14, La15, La25, La27, La28, La3, La31, La32, La36, La37, La46, La54, La58, La60, La62, Ma11, Ma18, Ma20, Ma21, Ma23, Ma24, Ma3, Ma31, Ma35, Ma37, Ma43, Ma50, Ma53, Ma56, Ma57, Ma6, Ma60, Ma74, Mo13a, Mo29b, Mo34a, Mo36a, Mo37a, Mo40b, Mo47a, Mo52b, Mo79b and Mo80b.
[4]	"Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism." Tsaur S.-C., Ting C.-T., Wu C.-I. Mol. Biol. Evol. 15:1040-1046(1998) [PubMed: 9718731] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-64; ARG-77; VAL-80; ILE-89 AND GLU-90. Strain: AF1, AF10, AF2, AF3, AF4, AF5, AF6, AF7, AF8, AF9, Au1, Au10, Au2, Au3, Au4, Au5, Au6, Au7, Au8, Au9, NC-001, NC-002, NC-003, NC-004, NC-005, NC-006, NC-007, NC-008, NC-010, NC-098, Ny1, Ny2, Ny3, Ny4, Ny5, Ny6, Ny7, Ny8, TW1, TW10, TW11, TW2, TW3, TW4, TW5, TW6, TW7, TW8 and TW9.
[5]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[6]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[7]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y00219 Genomic DNA. Translation: CAA68367.1. X70888 Genomic DNA. Translation: CAA50233.1. X70889 Genomic DNA. Translation: CAA50235.1. X70890 Genomic DNA. Translation: CAA50237.1. X70891 Genomic DNA. Translation: CAA50239.1. X70892 Genomic DNA. Translation: CAA50241.1. X70893 Genomic DNA. Translation: CAA50243.1. X70894 Genomic DNA. Translation: CAA50245.1. X70895 Genomic DNA. Translation: CAA50247.1. X70896 Genomic DNA. Translation: CAA50249.1. X70897 Genomic DNA. Translation: CAA50251.1. AJ231350 Genomic DNA. Translation: CAB37195.1. AJ231351 Genomic DNA. Translation: CAB37197.1. AJ231352 Genomic DNA. Translation: CAB37199.1. AJ231353 Genomic DNA. Translation: CAB37201.1. AJ231354 Genomic DNA. Translation: CAB37203.1. AJ231355 Genomic DNA. Translation: CAB37205.1. AJ231356 Genomic DNA. Translation: CAB37207.1. AJ231357 Genomic DNA. Translation: CAB37209.1. AJ231358 Genomic DNA. Translation: CAB37211.1. AJ231359 Genomic DNA. Translation: CAB37213.1. AJ231360 Genomic DNA. Translation: CAB37215.1. AJ231361 Genomic DNA. Translation: CAB37217.1. AJ231362 Genomic DNA. Translation: CAB37219.1. AJ231363 Genomic DNA. Translation: CAB37221.1. AJ231364 Genomic DNA. Translation: CAB37223.1. AJ231365 Genomic DNA. Translation: CAB37225.1. AJ231366 Genomic DNA. Translation: CAB37227.1. AJ231367 Genomic DNA. Translation: CAB37229.1. AJ231368 Genomic DNA. Translation: CAB37231.1. AJ231369 Genomic DNA. Translation: CAB37233.1. AJ231370 Genomic DNA. Translation: CAB37235.1. AJ231371 Genomic DNA. Translation: CAB37237.1. AJ231372 Genomic DNA. Translation: CAB37239.1. AJ231373 Genomic DNA. Translation: CAB37241.1. AJ231374 Genomic DNA. Translation: CAB37624.1. AJ231375 Genomic DNA. Translation: CAB37243.1. AJ231376 Genomic DNA. Translation: CAB37245.1. AJ231377 Genomic DNA. Translation: CAB37247.1. AJ231378 Genomic DNA. Translation: CAB37249.1. AJ231379 Genomic DNA. Translation: CAB37251.1. AJ231380 Genomic DNA. Translation: CAB37253.1. AJ231381 Genomic DNA. Translation: CAB37255.1. AJ231382 Genomic DNA. Translation: CAB37257.1. AJ231383 Genomic DNA. Translation: CAB37259.1. AJ231384 Genomic DNA. Translation: CAB37261.1. AJ231385 Genomic DNA. Translation: CAB37263.1. AJ231386 Genomic DNA. Translation: CAB37265.1. AJ231387 Genomic DNA. Translation: CAB37267.1. AJ231388 Genomic DNA. Translation: CAB37269.1. AJ231389 Genomic DNA. Translation: CAB37271.1. AJ231390 Genomic DNA. Translation: CAB37273.1. AJ231391 Genomic DNA. Translation: CAB37275.1. AJ231392 Genomic DNA. Translation: CAB37277.1. AJ231393 Genomic DNA. Translation: CAB37279.1. AJ231394 Genomic DNA. Translation: CAB37281.1. AJ231395 Genomic DNA. Translation: CAB37283.1. AJ231396 Genomic DNA. Translation: CAB37285.1. AJ231397 Genomic DNA. Translation: CAB37287.1. AJ231398 Genomic DNA. Translation: CAB37289.1. AJ231399 Genomic DNA. Translation: CAB37291.1. AJ231400 Genomic DNA. Translation: CAB37293.1. AJ231401 Genomic DNA. Translation: CAB37629.1. AF052470 Genomic DNA. Translation: AAC27996.1. AF052471 Genomic DNA. Translation: AAC27998.1. AF052472 Genomic DNA. Translation: AAC28000.1. AF052473 Genomic DNA. Translation: AAC28002.1. AF052474 Genomic DNA. Translation: AAC28004.1. AF052475 Genomic DNA. Translation: AAC28006.1. AF052476 Genomic DNA. Translation: AAC28008.1. AF052477 Genomic DNA. Translation: AAC28010.1. AF052478 Genomic DNA. Translation: AAC28012.1. AF052479 Genomic DNA. Translation: AAC28014.1. AF052480 Genomic DNA. Translation: AAC28016.1. AF052481 Genomic DNA. Translation: AAC28018.1. AF053250 Genomic DNA. Translation: AAC28791.1. AF053251 Genomic DNA. Translation: AAC28793.1. AF053252 Genomic DNA. Translation: AAC28795.1. AF053253 Genomic DNA. Translation: AAC28797.1. AF053254 Genomic DNA. Translation: AAC28799.1. AF053255 Genomic DNA. Translation: AAC28801.1. AF053256 Genomic DNA. Translation: AAC28803.1. AF053257 Genomic DNA. Translation: AAC28805.1. AF053258 Genomic DNA. Translation: AAC28807.1. AF053259 Genomic DNA. Translation: AAC28809.1. AF053260 Genomic DNA. Translation: AAC28811.1. AF053261 Genomic DNA. Translation: AAC28813.1. AF053262 Genomic DNA. Translation: AAC28815.1. AF053263 Genomic DNA. Translation: AAC28817.1. AF053264 Genomic DNA. Translation: AAC28819.1. AF053265 Genomic DNA. Translation: AAC28821.1. AF053266 Genomic DNA. Translation: AAC28823.1. AF053267 Genomic DNA. Translation: AAC28825.1. AF053268 Genomic DNA. Translation: AAC28827.1. AF053269 Genomic DNA. Translation: AAC28829.1. AF053270 Genomic DNA. Translation: AAC28831.1. AF053271 Genomic DNA. Translation: AAC28833.1. AF053272 Genomic DNA. Translation: AAC28835.1. AF053273 Genomic DNA. Translation: AAC28837.1. AF053274 Genomic DNA. Translation: AAC28839.1. AF053275 Genomic DNA. Translation: AAC28841.1. AF053276 Genomic DNA. Translation: AAC28843.1. AE014134 Genomic DNA. Translation: AAF52297.1. AE014134 Genomic DNA. Translation: AAN10560.1. BT023248 mRNA. Translation: AAY55664.1. BT029418 mRNA. Translation: ABK57075.1. Different initiation.
PIR	S02854. S30412.
RefSeq	NP_476645.1. NP_599099.1.
UniGene	Dm.26738
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	CG9024. Drosophila melanogaster. [Contig view]
GeneID	33816.
KEGG	dme:Dmel_CG9024.
Organism-specific databases
FlyBase	FBgn0002856. Acp26Ab.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-007544-MON. DMEL-XXX-02:DMEL-XXX-02-007545-MON.
Gene expression databases
GermOnline	CG9024. Drosophila melanogaster.
Family and domain databases
InterPro	IPR008392. Acp26Ab. [Graphical view]
Pfam	PF05777. Acp26Ab. 1 hit. [Graphical view]
ProDom	P10334. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P10334.
ProtoNet	Search...

Entry information

Entry name

MS2B_DROME

Accession

Primary (citable) accession number: P10334
Secondary accession number(s): A0JQ48 , A4V091, O76300, O76302, O77456, O97184, O97185, O97456, O97460, Q4V3V8, Q95NY1, Q95NY2, Q95NY3, Q9V432

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	July 22, 2008
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project