Reviewed, UniProtKB/Swiss-Prot P11049 (CD37_HUMAN)

Names and origin

Protein names

Recommended name:
    Leukocyte antigen CD37
Alternative name(s):
    Tetraspanin-26
      Short name=Tspan-26
    CD_antigen=CD37

Gene names

Name:	CD37
Synonyms:	TSPAN26

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	B-lymphocytes.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid N-linked glycosylation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 281	281	Leukocyte antigen CD37
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Potential
	Topological domain	39 – 59	21	Extracellular Potential
	Transmembrane	60 – 74	15	Potential
	Topological domain	75 – 85	11	Cytoplasmic Potential
	Transmembrane	86 – 111	26	Potential
	Topological domain	112 – 241	130	Extracellular Potential
	Transmembrane	242 – 266	25	Potential
	Topological domain	267 – 281	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P11049-1 [UniParc]. Last modified November 1, 1990. Version 2. Checksum: 4342C5FB4479FDC8	FASTA	281	31,703
	10 20 30 40 50 60 MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV 70 80 90 100 110 120 LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR 130 140 150 160 170 180 DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS 190 200 210 220 230 240 CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN 250 260 270 280 NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen." Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 169:1497-1502(1989) [PubMed: 2466944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Erratum Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 172:1007-1007(1990) [PubMed: 2388030] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14046 mRNA. Translation: CAA32204.1. BT019851 mRNA. Translation: AAV38654.1. CR541877 mRNA. Translation: CAG46675.1. BC106752 mRNA. Translation: AAI06753.1. BC110379 mRNA. Translation: AAI10380.1.
PIR	A47629.
RefSeq	NP_001765.1.
UniGene	Hs.166556
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000104894. Homo sapiens. [Contig view]
GeneID	951.
Organism-specific databases
HGNC	HGNC:1666. CD37.
HPA	CAB002492.
MIM	151523. gene.
PharmGKB	PA26213.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P11049.
HOVERGEN	P11049.
Gene expression databases
CleanEx	HS_CD37.
GermOnline	ENSG00000104894. Homo sapiens.
Family and domain databases
InterPro	IPR000301. Transmem_4. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProDom	P11049. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CD37_HUMAN

Accession

Primary (citable) accession number: P11049
Secondary accession number(s): Q3KPF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1990
Last modified:	July 22, 2008
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)