Muscarinic acetylcholine receptor M1

Contribute

Send feedback

Reviewed, UniProtKB/Swiss-Prot P11229 (ACM1_HUMAN)

Last modified July 22, 2008. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
Muscarinic acetylcholine receptor M1

Gene names

Name:

CHRM1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subunit structure	Interacts with GPRASP2.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	acetylcholine receptor signaling, muscarinic pathway Traceable author statement. Source: ProtInc activation of protein kinase C activity Traceable author statement. Source: ProtInc muscarinic acetylcholine receptor, phospholipase C activating pathway Traceable author statement. Source: ProtInc nervous system development Traceable author statement. Source: ProtInc positive regulation of cell proliferation Traceable author statement. Source: ProtInc protein modification process Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Molecular function	muscarinic acetylcholine receptor activity Traceable author statement. Source: ProtInc phosphoinositide phospholipase C activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 460

460

Muscarinic acetylcholine receptor M1

Regions

Topological domain

1 – 24

Extracellular Potential

Transmembrane

25 – 47

1 Potential

Topological domain

48 – 61

Cytoplasmic Potential

Transmembrane

62 – 82

2 Potential

Topological domain

83 – 99

Extracellular Potential

Transmembrane

100 – 121

3 Potential

Topological domain

122 – 141

Cytoplasmic Potential

Transmembrane

142 – 164

4 Potential

Topological domain

165 – 186

Extracellular Potential

Transmembrane

187 – 209

5 Potential

Topological domain

210 – 366

157

Cytoplasmic Potential

Transmembrane

367 – 387

6 Potential

Topological domain

388 – 401

Extracellular Potential

Transmembrane

402 – 421

7 Potential

Topological domain

422 – 460

Cytoplasmic Potential

Amino acid modifications

Modified residue

428

Phosphothreonine Potential

Modified residue

451

Phosphoserine Potential

Modified residue

455

Phosphothreonine Potential

Modified residue

457

Phosphoserine Potential

Glycosylation

N-linked (GlcNAc...) Probable

Glycosylation

N-linked (GlcNAc...) Probable

Disulfide bond

98 ↔ 178

By similarity

Experimental info

Sequence conflict

173

V → M in CAA33334. Ref.3

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

P11229-1 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: 567C20F63541C8D0
Show »

FASTA

460

51,421

        10         20         30         40         50         60 
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 

        70         80         90        100        110        120 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 

       130        140        150        160        170        180 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 

       190        200        210        220        230        240 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 

       250        260        270        280        290        300 
SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 

       310        320        330        340        350        360 
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 

       370        380        390        400        410        420 
KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 

       430        440        450        460 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor." Allard W.J., Sigal I.S., Dixon R.A.F. Nucleic Acids Res. 15:10604-10604(1987) [PubMed: 3697105] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification." Chapman C.G., Browne M.J. Nucleic Acids Res. 18:2191-2191(1990) [PubMed: 2336407] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors." Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., Capon D.J. EMBO J. 6:3923-3929(1987) [PubMed: 3443095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor." Arden J.R., Nagata O., Shockley M.S., Philip M., Lameh J., Sadee W. Biochem. Biophys. Res. Commun. 188:1111-1115(1992) [PubMed: 1445347] [Abstract] Cited for: MUTAGENESIS.
[7]	"Identification of a novel family of G protein-coupled receptor associated sorting proteins." Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L. J. Neurochem. 89:766-775(2004) [PubMed: 15086532] [Abstract] Cited for: INTERACTION WITH GPRASP2.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	X52068 Genomic DNA. Translation: CAA36291.1. X15263 Genomic DNA. Translation: CAA33334.1. Y00508 Genomic DNA. Translation: CAA68560.1. AF498915 mRNA. Translation: AAM18938.1. BC007740 mRNA. Translation: AAH07740.1. BC022984 mRNA. Translation: AAH22984.1.
PIR	S09508.
RefSeq	NP_000729.2.
UniGene	Hs.632119
3D structure databases
HSSP	HSSP built from PDB template 1HLL based on UniProtKB P08913.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSG00000168539. Homo sapiens. [Contig view]
GeneID	1128.
KEGG	hsa:1128.
Organism-specific databases
H-InvDB	HIX0009731.
HGNC	HGNC:1950. CHRM1.
HPA	HPA014101.
MIM	118510. gene.
PharmGKB	PA26484.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P11229.
HOVERGEN	P11229.
Gene expression databases
ArrayExpress	P11229.
CleanEx	HS_CHRM1.
GermOnline	ENSG00000168539. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002228. Musac_M1_rcpt. IPR000995. Musac_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00538. MUSCRINICM1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P11229. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
DrugBank	DB00517. Anisotropine Methylbromide. DB00572. Atropine. DB00767. Benzquinamide. DB00245. Benztropine. DB01019. Bethanechol. DB00810. Biperiden. DB00354. Buclizine. DB00411. Carbachol. DB00748. Carbinoxamine. DB00185. Cevimeline. DB00771. Clidinium. DB00785. Cryptenamine. DB01176. Cyclizine. DB00979. Cyclopentolate. DB00942. Cycrimine. DB01151. Desipramine. DB00804. Dicyclomine. DB01231. Diphenidol. DB00366. Doxylamine. DB00392. Ethopropazine. DB01148. Flavoxate. DB00986. Glycopyrrolate. DB00725. Homatropine Methylbromide. DB00424. Hyoscyamine. DB00332. Ipratropium. DB00940. Methantheline. DB01403. Methotrimeprazine. DB00462. Methylscopolamine. DB00340. Metixene. DB01233. Metoclopramide. DB00334. Olanzapine. DB01062. Oxybutynin. DB00383. Oxyphencyclimine. DB00219. Oxyphenonium. DB01085. Pilocarpine. DB00670. Pirenzepine. DB00387. Procyclidine. DB00420. Promazine. DB01069. Promethazine. DB00782. Propantheline. DB00777. Propiomazine. DB01103. Quinacrine. DB00747. Scopolamine. DB01591. Solifenacin. DB00202. Succinylcholine. DB00372. Thiethylperazine. DB01036. Tolterodine. DB00505. Tridihexethyl. DB00508. Triflupromazine. DB00376. Trihexyphenidyl. DB00209. Trospium.
SOURCE	Search...
ProtoNet	Search...

Hide | Top

Entry information

Entry name

ACM1_HUMAN

Accession

Primary (citable) accession number: P11229

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1990
Last modified:	July 22, 2008
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents