Reviewed, UniProtKB/Swiss-Prot P11617 (AA2AR_CANFA)

Names and origin

Protein names

Recommended name:
    Adenosine receptor A2a

Gene names

Name:	ADORA2A
Synonyms:	RDC8

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 412	412	Adenosine receptor A2a
Regions
	Topological domain	1 – 7	7	Extracellular Potential
	Transmembrane	8 – 30	23	1 Potential
	Topological domain	31 – 43	13	Cytoplasmic Potential
	Transmembrane	44 – 66	23	2 Potential
	Topological domain	67 – 77	11	Extracellular Potential
	Transmembrane	78 – 100	23	3 Potential
	Topological domain	101 – 120	20	Cytoplasmic Potential
	Transmembrane	121 – 143	23	4 Potential
	Topological domain	144 – 173	30	Extracellular Potential
	Transmembrane	174 – 198	25	5 Potential
	Topological domain	199 – 234	36	Cytoplasmic Potential
	Transmembrane	235 – 258	24	6 Potential
	Topological domain	259 – 266	8	Extracellular Potential
	Transmembrane	267 – 290	24	7 Potential
	Topological domain	291 – 412	122	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Disulfide bond	77 ↔ 166		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11617-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: EB1B094AD581C6A7	FASTA	412	45,061
	10 20 30 40 50 60 MSTMGSWVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI 70 80 90 100 110 120 PFAITISTGF CAACHNCLFF ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR 130 140 150 160 170 180 AKGIIAVCWV LSFAIGLTPM LGWNNCSQPK EGRNYSQGCG EGQVACLFED VVPMNYMVYY 190 200 210 220 230 240 NFFAFVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG 250 260 270 280 290 300 LFALCWLPLH IINCFTFFCP ECSHAPLWLM YLTIVLSHTN SVVNPFIYAY RIREFRQTFR 310 320 330 340 350 360 KIIRSHVLRR REPFKAGGTS ARALAAHGSD GEQISLRLNG HPPGVWANGS APHPERRPNG 370 380 390 400 410 YTLGLVSGGI APESHGDMGL PDVELLSHEL KGACPESPGL EGPLAQDGAG VS

References

[1]	"Selective amplification and cloning of four new members of the G protein-coupled receptor family." Libert F., Parmentier M., Lefort A., Dinsart C., van Sande J., Maenhaut C., Simons M.-J., Dumont J.E., Vassart G. Science 244:569-572(1989) [PubMed: 2541503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.
[2]	"Complete nucleotide sequence of a putative G protein coupled receptor: RDC8." Libert F., Parmentier M., Lefort A., Dumont J.E., Vassart G. Nucleic Acids Res. 18:1914-1914(1990) [PubMed: 2159628] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.
[3]	"RDC8 codes for an adenosine A2 receptor with physiological constitutive activity." Maenhaut C., van Sande J., Libert F., Abramowicz M., Parmentier M., Vanderhaegen J.-J., Dumont J.E., Vassart G., Schiffmann S. Biochem. Biophys. Res. Commun. 173:1169-1178(1990) [PubMed: 2125216] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14052 mRNA. Translation: CAA32210.1.
PIR	D30341.
RefSeq	NP_001003278.1.
UniGene	Cfa.3818
3D structure databases
HSSP	HSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSCAFG00000013828. Canis familiaris. [Contig view]
GeneID	403960.
KEGG	cfa:403960.
Phylogenomic databases
HOVERGEN	P11617.
Family and domain databases
InterPro	IPR001513. Adeno_A2A_rcpt. IPR001634. Adenosn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00553. ADENOSINA2AR. PR00424. ADENOSINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	P11617. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AA2AR_CANFA

Accession

Primary (citable) accession number: P11617

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	July 22, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)