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P13792

- PHOP_BACSU

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Protein
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Gene
phoP, BSU29110

Gene:

phoP, BSU29110
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - - Experimental evidence at protein leveli

UniProt

P13792 - PHOP_BACSU

Protein:

Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Protein Existence: Experimental evidence at protein level

Functioni

Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase.

GO - Molecular functioni

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA bindingInferred from electronic annotationi Source: UniProtKB-KW
  2. phosphorelay response regulator activityInferred from electronic annotationi Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phosphate transport, Transcription, Transcription regulation, Transport, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU29110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
Gene namesi
Name:phoP
Ordered Locus Names:BSU29110
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU29110. [Micado]

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasmInferred from electronic annotationi Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Chaini1 – 240240Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
PRO_0000081194

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Modified residuei5314-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by PhoR Inferred.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13792.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU29110.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Beta strandi4 – 85
Helixi12 – 2413
Beta strandi28 – 347
Helixi35 – 4511
Beta strandi48 – 558
Beta strandi57 – 593
Helixi61 – 7010
Beta strandi77 – 815
Helixi89 – 946
Beta strandi99 – 1046
Helixi107 – 11913

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVOX-ray1.60A1-135[»]
ProteinModelPortaliP13792.
SMRiP13792. Positions 1-237.

Miscellaneous databases

EvolutionaryTraceiP13792.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Domaini4 – 118115Response regulatory

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
KOiK07658.
OrthoDBiEOG6G4VQG.
ProtClustDBiCLSK2393393.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13792-1 [UniParc]FASTA

« Hide

MNKKILVVDD EESIVTLLQY NLERSGYDVI TASDGEEALK KAETEKPDLI    50
VLDVMLPKLD GIEVCKQLRQ QKLMFPILML TAKDEEFDKV LGLELGADDY 100
MTKPFSPREV NARVKAILRR SEIAAPSSEM KNDEMEGQIV IGDLKILPDH 150
YEAYFKESQL ELTPKEFELL LYLGRHKGRV LTRDLLLSAV WNYDFAGDTR 200
IVDVHISHLR DKIENNTKKP IYIKTIRGLG YKLEEPKMNE 240
Length:240
Mass (Da):27,598
Last modified:July 7, 2009 - v4
Checksum:iE61A6FADBE513D97
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflicti1241A → R in AAA22661. 1 Publication
Sequence conflicti1241A → R in AAC00348. 1 Publication
Sequence conflicti1541Y → I in AAA22661. 1 Publication
Sequence conflicti2111D → PT in AAA22661. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67676 Genomic DNA. Translation: CAA47908.1.
M16775 Genomic DNA. Translation: AAA22661.1.
AF008220 Genomic DNA. Translation: AAC00348.1.
AL009126 Genomic DNA. Translation: CAB14871.2.
U05257 Genomic DNA. Translation: AAA96344.1.
M23549 Genomic DNA. Translation: AAA22662.1.
PIRiRGBSAP. F69676.
RefSeqiNP_390789.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14871; CAB14871; BSU29110.
GeneIDi936644.
KEGGibsu:BSU29110.
PATRICi18977714. VBIBacSub10457_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67676 Genomic DNA. Translation: CAA47908.1 .
M16775 Genomic DNA. Translation: AAA22661.1 .
AF008220 Genomic DNA. Translation: AAC00348.1 .
AL009126 Genomic DNA. Translation: CAB14871.2 .
U05257 Genomic DNA. Translation: AAA96344.1 .
M23549 Genomic DNA. Translation: AAA22662.1 .
PIRi RGBSAP. F69676.
RefSeqi NP_390789.2. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MVO X-ray 1.60 A 1-135 [» ]
ProteinModelPortali P13792.
SMRi P13792. Positions 1-237.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224308.BSU29110.

Proteomic databases

PaxDbi P13792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14871 ; CAB14871 ; BSU29110 .
GeneIDi 936644.
KEGGi bsu:BSU29110.
PATRICi 18977714. VBIBacSub10457_3045.

Organism-specific databases

GenoListi BSU29110. [Micado ]

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
KOi K07658.
OrthoDBi EOG6G4VQG.
ProtClustDBi CLSK2393393.

Enzyme and pathway databases

BioCyci BSUB:BSU29110-MONOMER.

Miscellaneous databases

EvolutionaryTracei P13792.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publicationsDownload
  1. "Nucleotide sequence of the phoP gene encoding PhoP, the response regulator of the phosphate regulon of Bacillus subtilis."
    Lee J.W., Hulett F.M.
    Nucleic Acids Res. 20:5848-5848(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis."
    Seki T., Yoshikawa H., Takahashi H., Saito H.
    J. Bacteriol. 169:2913-2916(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
    Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
    Microbiology 143:3431-3441(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  4. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  5. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 124.
  6. "Identification of two distinct Bacillus subtilis citrate synthase genes."
    Jin S., Sonenshein A.L.
    J. Bacteriol. 176:4669-4679(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
    Strain: 168 / SMY.
  7. "Nucleotide sequence of the Bacillus subtilis phoR gene."
    Seki T., Yoshikawa H., Takahashi H., Saito H.
    J. Bacteriol. 170:5935-5938(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-240.

Entry nameiPHOP_BACSU
AccessioniPrimary (citable) accession number: P13792
Secondary accession number(s): O34804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: April 16, 2014
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

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