Reviewed, UniProtKB/Swiss-Prot P15787 (MT2_COLLI)

Names and origin

Protein names	Recommended name:     Metallothionein-2       Short name=MT-2 Alternative name(s):     Metallothionein-II       Short name=MT-II
Organism	Columba livia (Domestic pigeon)
Taxonomic identifier	8932 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Columbiformes › Columbidae › Columba

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 63	63	Metallothionein-2
Regions
	Region	1 – 30	30	Beta
	Region	31 – 63	33	Alpha
Sites
	Metal binding	6	1	Cluster B
	Metal binding	8	1	Cluster B
	Metal binding	14	1	Cluster B
	Metal binding	16	1	Cluster B
	Metal binding	20	1	Cluster B
	Metal binding	22	1	Cluster B
	Metal binding	25	1	Cluster B
	Metal binding	27	1	Cluster B
	Metal binding	30	1	Cluster B
	Metal binding	34	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	38	1	Cluster A
	Metal binding	42	1	Cluster A
	Metal binding	45	1	Cluster A
	Metal binding	49	1	Cluster A
	Metal binding	51	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	61	1	Cluster A
	Metal binding	62	1	Cluster A

Sequences

	Sequence		Length	Mass (Da)
	P15787-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A2B84227E94C365E	FASTA	63	6,452
	10 20 30 40 50 60 MDPQDCTCAA GDSCSCAGSC KCKNCRCQSC RKSCCSCCPA SCSNCAKGCV CKEPSSSKCS CCH

References

[1]	"Pigeon metallothionein consists of two species." Lin L.-Y., Lin W.C., Huang P.C. Biochim. Biophys. Acta 1037:248-255(1990) [PubMed: 2407296] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	S08191.
3D structure databases
HSSP	HSSP built from PDB template 2MHU based on UniProtKB P02795.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P15787.
Family and domain databases
InterPro	IPR015874. 4-disulphide_core. IPR002400. GF_cysknot. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR001008. Metallthion_2. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00003. 4DISULPHCORE. PR00438. GFCYSKNOT. PR00875. MTMOLLUSC. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	P15787. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT2_COLLI

Accession

Primary (citable) accession number: P15787

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	November 1, 1997
Last modified:	July 22, 2008
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)