T-cell surface glycoprotein CD1e precursor

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Reviewed, UniProtKB/Swiss-Prot P15812 (CD1E_HUMAN)

Last modified July 22, 2008. Version 79. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    T-cell surface glycoprotein CD1e
Alternative name(s):
    R2G1
    CD_antigen=CD1e

Gene names

Name:

CD1E

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Required for the presentation of glycolipid antigens on the cell surface.
Subunit structure	Heterodimer with B2M (beta-2-microglobulin).
Subcellular location	Golgi apparatus membrane; Single-pass type I membrane protein. Endosome lumen. Lysosome lumen. Note= Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.
Tissue specificity	Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
Post-translational modification	Mono-ubiquitinated. Proteolytically cleaved in endosomes to yield a soluble form.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

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Ontologies

Keywords
Biological process	Immune response
Cellular component	Endosome Golgi apparatus Lysosome Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane
PTM	Glycoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

1 – 19

Chain

20 – 322

303

T-cell surface glycoprotein CD1e

Regions

Topological domain

20 – 294

275

Extracellular Potential

Transmembrane

295 – 315

Potential

Topological domain

316 – 322

Cytoplasmic Potential

Domain

181 – 291

111

Ig-like

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 180

By similarity

Disulfide bond

220 ↔ 275

By similarity

Natural variations

Natural variant

Natural variant

Natural variant

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Sequences

Sequence

Length

Mass (Da)

Tools

P15812-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: E08F97051A0D9660
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FASTA

322

35,986

        10         20         30         40         50         60 
MLLLFLLFEG LCCPGENTAA AEEQLSFRML QTSSFANHSW AHSEGSGWLG DLQTHGWDTV 

        70         80         90        100        110        120 
LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP FEIQILAGCR 

       130        140        150        160        170        180 
MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC 

       190        200        210        220        230        240 
PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE 

       250        260        270        280        290        300 
QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL 

       310        320 
ICLTVIVTLV ILVVVDSRLK KQ

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References

[1]	"Two classes of CD1 genes." Calabi F., Jarvis J.M., Martin L., Milstein C. Eur. J. Immunol. 19:285-292(1989) [PubMed: 2467814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Polymorphism of human CD1 genes." Han M., Hannick L.I., DiBrino M., Robinson M.A. Tissue Antigens 54:122-127(1999) [PubMed: 10488738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-108, VARIANT ARG-96.
[3]	"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens." Martin L.H., Calabi F., Milstein C. Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed: 3097645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-291.
[4]	"Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells." Angenieux C., Salamero J., Fricker D., Cazenave J.-P., Goud B., Hanau D., de La Salle H. J. Biol. Chem. 275:37757-37764(2000) [PubMed: 10948205] [Abstract] Cited for: FUNCTION, INTERACTION WITH B2M, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[5]	"Assistance of microbial glycolipid antigen processing by CD1e." de la Salle H., Mariotti S., Angenieux C., Gilleron M., Garcia-Alles L.-F., Malm D., Berg T., Paoletti S., Maitre B., Mourey L., Salamero J., Cazenave J.-P., Hanau D., Mori L., Puzo G., De Libero G. Science 310:1321-1324(2005) [PubMed: 16311334] [Abstract] Cited for: FUNCTION.
[6]	"Control of the intracellular pathway of CD1e." Maitre B., Angenieux C., Salamero J., Hanau D., Fricker D., Signorino F., Proamer F., Cazenave J.-P., Goud B., Tourne S., de la Salle H. Traffic 9:431-445(2008) [PubMed: 18208508] [Abstract] Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PROTEOLYTIC PROCESSING.
[7]	"Identification of two novel human CD1E alleles." Mirones I., Oteo M., Parra-Cuadrado J.F., Martinez-Naves E. Tissue Antigens 56:159-161(2000) [PubMed: 11019917] [Abstract] Cited for: VARIANTS TRP-154 AND PRO-184.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X14975 Genomic DNA. Translation: CAA33100.1. Different termination. AF142669 Genomic DNA. Translation: AAD37582.1. AJ251334 Genomic DNA. Translation: CAB82829.1. AJ251335 Genomic DNA. Translation: CAC07175.1. M14666 Genomic DNA. Translation: AAA51937.1.
PIR	HLHUR2. S07716.
UniGene	Hs.249217
3D structure databases
HSSP	HSSP built from PDB template 1GZQ based on UniProtKB P29016.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000158488. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:1638. CD1E.
MIM	188411. gene.
PharmGKB	PA26197.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P15812.
Gene expression databases
ArrayExpress	P15812.
CleanEx	HS_CD1E.
GermOnline	ENSG00000158488. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. [Graphical view]
SMART	SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProDom	P15812. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P15812.
SOURCE	Search...
ProtoNet	Search...

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Entry information

Entry name

CD1E_HUMAN

Accession

Primary (citable) accession number: P15812
Secondary accession number(s): Q9UMM1, Q9Y5M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	July 22, 2008
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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