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Reviewed, UniProtKB/Swiss-Prot P17277 (HXA4_CHICK)

Last modified July 22, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A4
Alternative name(s):
    Chox-1.4
Gene names
Name: HOXA4
Synonyms: CHOX-1.4
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Subcellular location

Nucleus.

Domain

The proline stretch works as a part of the transcriptional activation domain.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 309309Homeobox protein Hox-A4

Regions

DNA binding209 – 26860Homeobox
Motif188 – 1936Antp-type hexapeptide
Compositional bias38 – 148111Pro-rich

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Sequences

Sequence LengthMass (Da)Tools
P17277-1 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 8898A41502319341

FASTA30933,478
        10         20         30         40         50         60 
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA 

        70         80         90        100        110        120 
HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG 

       130        140        150        160        170        180 
PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG 

       190        200        210        220        230        240 
LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI 

       250        260        270        280        290        300 
EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD 


GAAPNAAAL

« Hide

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References

[1]"Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
Sasaki H., Yokoyama E., Kuroiwa A.
Nucleic Acids Res. 18:1739-1747(1990) [PubMed: 1970866] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and analysis of chick homeobox cDNA clones."
Scotting P.J., Hewitt M., Keynes R.J.
Nucleic Acids Res. 18:3999-3999(1990) [PubMed: 1973835] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
Strain: Comet Hubbard hybrid.

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Cross-references

Sequence databases

X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRS09257.
RefSeqNP_001025517.1.
UniGeneGga.4243

3D structure databases

HSSPHSSP built from PDB template 9ANT based on UniProtKB P02833.
SMRP17277. Positions 210-269.
ModBaseSearch...

Genome annotation databases

EnsemblENSGALG00000011055. Gallus gallus. [Contig view]
GeneID395307.
KEGGgga:395307.

Phylogenomic databases

HOGENOMP17277.
HOVERGENP17277.

Family and domain databases

InterProIPR001827. Antennapedia.
IPR001356. Homeobox.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameHXA4_CHICK
AccessionPrimary (citable) accession number: P17277
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 22, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents