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Reviewed, UniProtKB/Swiss-Prot P21192 (ACE2_YEAST)

Last modified November 4, 2008. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Metallothionein expression activator
Gene names
Name: ACE2
Ordered Locus Names: YLR131C
ORF Names: L3123, L9606.10
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length770 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.

Subcellular location

Nucleus.

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

Sequence similarities

Contains 3 C2H2-type zinc fingers.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processregulation of transcription during G1 phase of mitotic cell cycle

Inferred from direct assay. Source: SGD

   Cellular componentcytosol

Inferred from direct assay. Source: SGD

nucleus

Inferred from direct assay. Source: SGD

   Molecular functiontranscription activator activity

Inferred from mutant phenotype. Source: SGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 770770Metallothionein expression activator
PRO_0000046800

Regions

Zinc finger603 – 62725C2H2-type 1
Zinc finger633 – 65725C2H2-type 2
Zinc finger662 – 68524C2H2-type 3; atypical

Amino acid modifications

Modified residue801Phosphoserine
Modified residue1221Phosphoserine
Modified residue2491Phosphoserine
Modified residue2531Phosphoserine
Modified residue4281Phosphoserine
Modified residue5011Phosphothreonine
Modified residue5641Phosphoserine
Modified residue7011Phosphoserine
Modified residue7091Phosphoserine

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Sequences

Sequence LengthMass (Da)Tools
P21192-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: A7FCA8C506A2FD75

FASTA77086,634
        10         20         30         40         50         60 
MDNVVDPWYI NPSGFAKDTQ DEEYVQHHDN VNPTIPPPDN YILNNENDDG LDNLLGMDYY 

        70         80         90        100        110        120 
NIDDLLTQEL RDLDIPLVPS PKTGDGSSDK KNIDRTWNLG DENNKVSHYS KKSMSSHKRG 

       130        140        150        160        170        180 
LSGTAIFGFL GHNKTLSISS LQQSILNMSK DPQPMELINE LGNHNTVKNN NDDFDHIREN 

       190        200        210        220        230        240 
DGENSYLSQV LLKQQEELRI ALEKQKEVNE KLEKQLRDNQ IQQEKLRKVL EEQEEVAQKL 

       250        260        270        280        290        300 
VSGATNSNSK PGSPVILKTP AMQNGRMKDN AIIVTTNSAN GGYQFPPPTL ISPRMSNTSI 

       310        320        330        340        350        360 
NGSPSRKYHR QRYPNKSPES NGLNLFSSNS GYLRDSELLS FSPQNYNLNL DGLTYNDHNN 

       370        380        390        400        410        420 
TSDKNNNDKK NSTGDNIFRL FEKTSPGGLS ISPRINGNSL RSPFLVGTDK SRDDRYAAGT 

       430        440        450        460        470        480 
FTPRTQLSPI HKKRESVVST VSTISQLQDD TEPIHMRNTQ NPTLRNANAL ASSSVLPPIP 

       490        500        510        520        530        540 
GSSNNTPIKN SLPQKHVFQH TPVKAPPKNG SNLAPLLNAP DLTDHQLEIK TPIRNNSHCE 

       550        560        570        580        590        600 
VESYPQVPPV THDIHKSPTL HSTSPLPDEI IPRTTPMKIT KKPTTLPPGT IDQYVKELPD 

       610        620        630        640        650        660 
KLFECLYPNC NKVFKRRYNI RSHIQTHLQD RPYSCDFPGC TKAFVRNHDL IRHKISHNAK 

       670        680        690        700        710        720 
KYICPCGKRF NREDALMVHR SRMICTGGKK LEHSINKKLT SPKKSLLDSP HDTSPVKETI 

       730        740        750        760        770 
ARDKDGSVLM KMEEQLRDDM RKHGLLDPPP STAAHEQNSN RTLSNETDAL

« Hide

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References

« Hide 'large scale' references
[1]"ACE2, an activator of yeast metallothionein expression which is homologous to SWI5."
Butler G., Thiele D.J.
Mol. Cell. Biol. 11:476-485(1991) [PubMed: 1986241] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBY939.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed: 9169871] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae."
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M., Shabanowitz J., Hunt D.F., White F.M.
Nat. Biotechnol. 20:301-305(2002) [PubMed: 11875433] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, MASS SPECTROMETRY.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-122, MASS SPECTROMETRY.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY.
[7]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428 AND THR-501, MASS SPECTROMETRY.
[8]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, MASS SPECTROMETRY.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249; SER-253; SER-564 AND SER-709, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M55619 Genomic DNA. Translation: AAA34387.1.
X91258 Genomic DNA. Translation: CAA62643.1.
Z73303 Genomic DNA. Translation: CAA97702.1.
U53881 Genomic DNA. Translation: AAB82398.1.
PIRTWBYA2. S12943.
RefSeqNP_013232.1.

3D structure databases

HSSPHSSP built from PDB template 1ZFD based on UniProtKB P08153.
SMRP21192. Positions 585-631.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2012N.
IntActP21192.

Proteomic databases

PeptideAtlasP21192.

Genome annotation databases

EnsemblYLR131C. Saccharomyces cerevisiae. [Contig view]
GeneID850822.
GenomeReviewsGene locus YLR131C in contig Y13138_GR.
KEGGsce:YLR131C.
NMPDRfig|4932.3.peg.4225.

Organism-specific databases

CYGDYLR131c.
SGDS000004121. ACE2.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP21192.

Gene expression databases

ArrayExpressP21192.
GermOnlineYLR131C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

LinkHubP21192.
NextBio967073.

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Entry information

Entry nameACE2_YEAST
AccessionPrimary (citable) accession number: P21192
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 4, 2008
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents