Reviewed, UniProtKB/Swiss-Prot P21518 (ADH_DROAF)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:

Adh

Organism

Drosophila affinidisjuncta (Fruit fly) (Idiomyia affinidisjuncta)

Taxonomic identifier

7262 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Hawaiian Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Alcohol dehydrogenase
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21518-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C39E868008CB1FDF	FASTA	254	27,437
	10 20 30 40 50 60 MVIANSNVIF VAGLGGIGLD TSREIVKSGP KNLVVLDRVD NPAAIAELKA LNPKVTVTFY 70 80 90 100 110 120 PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDNQI ERTIAVNFTG TVNTTTAIMD 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNSIYQVPV YSASKAAALS FTTSIAKLAH ITGVTAYSIN 190 200 210 220 230 240 PGITKTVLVH KFNSWLSVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR 250 LDAIEWTKHW DSGI

References

[1]	"Nucleotide sequence of the genomic region encoding alcohol dehydrogenase in Drosophila affinidisjuncta." Rowan R.G., Dickinson W.J. J. Mol. Evol. 28:43-54(1988) [PubMed: 3148741] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	McKenzie R.W., Brennan M.D. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S36G1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X13812 Genomic DNA. Translation: CAA32041.1. M37262 Genomic DNA. Translation: AAA28336.1. U63563 mRNA. Translation: AAB07872.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	P21518. Positions 1-254.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012073. Daff\Adh.
Family and domain databases
InterPro	IPR002198. DHase_sc/Rdtase_SDR. IPR002425. Insect_AlcDHase. IPR002424. Insect_AlcDHase_fam. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ADH_DROAF

Accession

Primary (citable) accession number: P21518

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project